Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study
IntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and advanced liver fibrosis in patients with clinical and...
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Frontiers Media S.A.
2022-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.808417/full |
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| author | Pedro Landete Pedro Landete Carlos Ernesto Fernández-García Beatriz Aldave-Orzaiz Marta Hernández-Olivo Carmen M. Acosta-Gutiérrez Enrique Zamora-García Enrique Zamora-García Julio Ancochea Julio Ancochea Águeda González-Rodríguez Águeda González-Rodríguez Carmelo García-Monzón |
| author_facet | Pedro Landete Pedro Landete Carlos Ernesto Fernández-García Beatriz Aldave-Orzaiz Marta Hernández-Olivo Carmen M. Acosta-Gutiérrez Enrique Zamora-García Enrique Zamora-García Julio Ancochea Julio Ancochea Águeda González-Rodríguez Águeda González-Rodríguez Carmelo García-Monzón |
| author_sort | Pedro Landete |
| collection | DOAJ |
| description | IntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and advanced liver fibrosis in patients with clinical and polygraphic criteria of OSA (n = 153) and in subjects with normal lung function parameters (NLP, n = 43).MethodsHepatosteatosis, NASH, and advanced liver fibrosis were determined by blood-based non-invasive tools, such as the fatty liver index and the hepatic steatosis index, a serum lipidomic (OWLiver™) test, and three distinct fibrosis algorithms, respectively. Logistic regression models adjusted by potential confounders were performed to evaluate risk factors.ResultsInsulin resistance and dyslipidemia were more frequent in patients with OSA than in subjects with NLP. The prevalence of hepatosteatosis was significantly higher in patients with OSA than in subjects with NLP. NASH was also found more frequently in patients with OSA than in subjects with NLP. In contrast, advanced liver fibrosis was rarely detected in the entire study population, and no significant differences were observed between patients with OSA and subjects with NLP. Besides male gender, increased body mass index (BMI), and presence of type 2 diabetes, percentage of sleep time with oxygen saturation <90% (Tc90%) was the only polygraphic variable significantly associated with NASH in patients with OSA.ConclusionsThis study shows that hepatosteatosis and NASH are highly prevalent in patients with OSA and indicates that those with a Tc90% higher than 10% are at increased risk for NASH. |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T14:02:32Z |
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| spelling | doaj.art-430de82f9bb24490b26742eef4c1c71b2022-12-21T23:42:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-02-01910.3389/fmed.2022.808417808417Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort StudyPedro Landete0Pedro Landete1Carlos Ernesto Fernández-García2Beatriz Aldave-Orzaiz3Marta Hernández-Olivo4Carmen M. Acosta-Gutiérrez5Enrique Zamora-García6Enrique Zamora-García7Julio Ancochea8Julio Ancochea9Águeda González-Rodríguez10Águeda González-Rodríguez11Carmelo García-Monzón12Servicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainDepartamento de Medicina, Universidad Autónoma de Madrid, Madrid, SpainUnidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainServicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainServicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainServicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainServicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainDepartamento de Medicina, Universidad Autónoma de Madrid, Madrid, SpainServicio de Neumología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainDepartamento de Medicina, Universidad Autónoma de Madrid, Madrid, SpainUnidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, SpainUnidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, SpainIntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and advanced liver fibrosis in patients with clinical and polygraphic criteria of OSA (n = 153) and in subjects with normal lung function parameters (NLP, n = 43).MethodsHepatosteatosis, NASH, and advanced liver fibrosis were determined by blood-based non-invasive tools, such as the fatty liver index and the hepatic steatosis index, a serum lipidomic (OWLiver™) test, and three distinct fibrosis algorithms, respectively. Logistic regression models adjusted by potential confounders were performed to evaluate risk factors.ResultsInsulin resistance and dyslipidemia were more frequent in patients with OSA than in subjects with NLP. The prevalence of hepatosteatosis was significantly higher in patients with OSA than in subjects with NLP. NASH was also found more frequently in patients with OSA than in subjects with NLP. In contrast, advanced liver fibrosis was rarely detected in the entire study population, and no significant differences were observed between patients with OSA and subjects with NLP. Besides male gender, increased body mass index (BMI), and presence of type 2 diabetes, percentage of sleep time with oxygen saturation <90% (Tc90%) was the only polygraphic variable significantly associated with NASH in patients with OSA.ConclusionsThis study shows that hepatosteatosis and NASH are highly prevalent in patients with OSA and indicates that those with a Tc90% higher than 10% are at increased risk for NASH.https://www.frontiersin.org/articles/10.3389/fmed.2022.808417/fullnon-alcoholic fatty liver diseasesteatosisnon-alcoholic steatohepatitisobstructive sleep apnea syndromenocturnal intermittent hypoxia |
| spellingShingle | Pedro Landete Pedro Landete Carlos Ernesto Fernández-García Beatriz Aldave-Orzaiz Marta Hernández-Olivo Carmen M. Acosta-Gutiérrez Enrique Zamora-García Enrique Zamora-García Julio Ancochea Julio Ancochea Águeda González-Rodríguez Águeda González-Rodríguez Carmelo García-Monzón Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study Frontiers in Medicine non-alcoholic fatty liver disease steatosis non-alcoholic steatohepatitis obstructive sleep apnea syndrome nocturnal intermittent hypoxia |
| title | Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study |
| title_full | Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study |
| title_fullStr | Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study |
| title_full_unstemmed | Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study |
| title_short | Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study |
| title_sort | increased oxygen desaturation time during sleep is a risk factor for nash in patients with obstructive sleep apnea a prospective cohort study |
| topic | non-alcoholic fatty liver disease steatosis non-alcoholic steatohepatitis obstructive sleep apnea syndrome nocturnal intermittent hypoxia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.808417/full |
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