ML Flow serological test: complementary tool in leprosy
Abstract Background The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. Objective To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describi...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2023-06-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300331&tlng=en |
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| author | Janaína Olher Martins Montanha Susilene Maria Tonelli Nardi Fernanda Modesto Tolentino Binhardi Heloisa da Silveira Paro Pedro Milena Polotto de Santi Vânia Del Arco Paschoal |
| author_facet | Janaína Olher Martins Montanha Susilene Maria Tonelli Nardi Fernanda Modesto Tolentino Binhardi Heloisa da Silveira Paro Pedro Milena Polotto de Santi Vânia Del Arco Paschoal |
| author_sort | Janaína Olher Martins Montanha |
| collection | DOAJ |
| description | Abstract Background The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. Objective To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describing the epidemiological profile of both. Methods Prospective study with patients diagnosed over the course of one year (n = 26), without prior treatment, and their household contacts (n = 44) in six municipalities in northwestern São Paulo, Brazil. Results There was a predominance of men among the leprosy cases, of 61.5% (16/26); 77% (20/26) were over 35 years old; 86.4% (22/26) were multibacillary; 61.5% (16/26) had a positive bacilloscopy; and 65.4% (17/26) had no physical disability. The ML Flow test was positive in 53.8% (14/26) of the leprosy cases and was associated with those who had a positive bacilloscopy and were diagnosed as multibacillary (p-value <0.05). Among the household contacts, 52.3% (23/44) were women and aged over 35 years; 81.8% (36/44) had been vaccinated with BCG ‒ Bacillus Calmette-Guérin. The ML Flow test was positive in 27.3% (12/44) of household contacts, all of whom lived with multibacillary cases; seven lived with positive bacilloscopy cases and six with consanguineous cases. Study limitations Difficulty in convincing the contacts to undergo the evaluation and collection of the clinical sample. Conclusion The ML Flow test, when positive in household contacts, can help the identification of cases that require more attention by the health team, as it indicates a predisposition to disease development, especially when they are household contacts of multibacillary cases, with positive bacilloscopy and consanguineous. The ML Flow test also helps in the correct clinical classification of the leprosy cases. |
| first_indexed | 2024-03-13T02:18:49Z |
| format | Article |
| id | doaj.art-430f325bf9a74e809b8d411d93b41bd6 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-03-13T02:18:49Z |
| publishDate | 2023-06-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-430f325bf9a74e809b8d411d93b41bd62023-06-30T10:49:53ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962023-06-0198333133810.1016/j.abd.2022.05.005ML Flow serological test: complementary tool in leprosyJanaína Olher Martins Montanhahttps://orcid.org/0000-0003-1710-2225Susilene Maria Tonelli Nardihttps://orcid.org/0000-0001-8793-8437Fernanda Modesto Tolentino Binhardihttps://orcid.org/0000-0002-2172-6594Heloisa da Silveira Paro Pedrohttps://orcid.org/0000-0002-5088-2510Milena Polotto de Santihttps://orcid.org/0000-0002-6419-7987Vânia Del Arco Paschoalhttps://orcid.org/0000-0002-6047-5345Abstract Background The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. Objective To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describing the epidemiological profile of both. Methods Prospective study with patients diagnosed over the course of one year (n = 26), without prior treatment, and their household contacts (n = 44) in six municipalities in northwestern São Paulo, Brazil. Results There was a predominance of men among the leprosy cases, of 61.5% (16/26); 77% (20/26) were over 35 years old; 86.4% (22/26) were multibacillary; 61.5% (16/26) had a positive bacilloscopy; and 65.4% (17/26) had no physical disability. The ML Flow test was positive in 53.8% (14/26) of the leprosy cases and was associated with those who had a positive bacilloscopy and were diagnosed as multibacillary (p-value <0.05). Among the household contacts, 52.3% (23/44) were women and aged over 35 years; 81.8% (36/44) had been vaccinated with BCG ‒ Bacillus Calmette-Guérin. The ML Flow test was positive in 27.3% (12/44) of household contacts, all of whom lived with multibacillary cases; seven lived with positive bacilloscopy cases and six with consanguineous cases. Study limitations Difficulty in convincing the contacts to undergo the evaluation and collection of the clinical sample. Conclusion The ML Flow test, when positive in household contacts, can help the identification of cases that require more attention by the health team, as it indicates a predisposition to disease development, especially when they are household contacts of multibacillary cases, with positive bacilloscopy and consanguineous. The ML Flow test also helps in the correct clinical classification of the leprosy cases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300331&tlng=enContact tracingLeprosyPublic healthSerologySurveillance |
| spellingShingle | Janaína Olher Martins Montanha Susilene Maria Tonelli Nardi Fernanda Modesto Tolentino Binhardi Heloisa da Silveira Paro Pedro Milena Polotto de Santi Vânia Del Arco Paschoal ML Flow serological test: complementary tool in leprosy Anais Brasileiros de Dermatologia Contact tracing Leprosy Public health Serology Surveillance |
| title | ML Flow serological test: complementary tool in leprosy |
| title_full | ML Flow serological test: complementary tool in leprosy |
| title_fullStr | ML Flow serological test: complementary tool in leprosy |
| title_full_unstemmed | ML Flow serological test: complementary tool in leprosy |
| title_short | ML Flow serological test: complementary tool in leprosy |
| title_sort | ml flow serological test complementary tool in leprosy |
| topic | Contact tracing Leprosy Public health Serology Surveillance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300331&tlng=en |
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