Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study
Background: Psoriasis is a chronic, immune mediated inflammatory condition of the skin and imbalance in inflammatory mediators could result in insulin resistance, metabolic syndrome and facilitate the occurrence and progression of Non-alcoholic fatty liver disease (NAFLD). Objectives: Primary object...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=377;epage=384;aulast=Yadav |
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| author | Vidya Yadav Vibhu Mendiratta Aparna Agrawal Kavita Bisherwal Ritu Singh Amit K Meena |
| author_facet | Vidya Yadav Vibhu Mendiratta Aparna Agrawal Kavita Bisherwal Ritu Singh Amit K Meena |
| author_sort | Vidya Yadav |
| collection | DOAJ |
| description | Background: Psoriasis is a chronic, immune mediated inflammatory condition of the skin and imbalance in inflammatory mediators could result in insulin resistance, metabolic syndrome and facilitate the occurrence and progression of Non-alcoholic fatty liver disease (NAFLD).
Objectives:
Primary objectives:
To study the frequency of NAFLD in cases of chronic plaque psoriasis and controlsTo study the interleukin levels in cases of chronic plaque psoriasis and controls.
Secondary objectives:
To study the BMI, lipid profile, waist circumference, FBS (fasting blood sugar), PPBS (post prandial blood sugar) and serum insulin in cases and controlsTo study the association of age, duration of psoriasis, PASI (psoriasis area severity index), BSA (body surface area) involved, BMI (body mass index), lipid profile, obesity, waist circumference, FBS (fasting blood sugar), PPBS (post prandial blood sugar) and serum insulin levels with NAFLD in patients of chronic plaque psoriasisTo correlate serum levels of IL1-β, IL6 and TNF-α with NAFLD in patients of chronic plaque psoriasis.
Methods: 50 clinically diagnosed cases of chronic plaque psoriasis with age ≥ 18years, diseases duration ≥ 6 months and 30 age and sex matched controls were recruited. PASI, BSA of cases was calculated and BMI, BP, WC of all subjects was measured. Serum lipid profile, FBS, PPBS, insulin level, IL1- β, IL6, TNF- α, high frequency B-mode ultrasound, LFT and fibroscan were done in all subjects. Results: 28(56.0%) cases and 2(6.6%) controls had NAFLD with statistically significant difference. Significantly elevated WC, serum insulin, deranged lipid profile, fatty liver, transaminitis, fibroscan score, liver fibrosis, NAFLD and interleukins were found in cases vs controls. There was a significant association of NAFLD in psoriatic patients with increasing duration of psoriasis, BMI ≥23 Kg/m2, high WC, increasing BSA involved, deranged lipid profile, raised total cholesterol levels and increasing number of risk factors. Nonsignificant but positive association of NAFLD in cases was found with high levels of IL1 – β, IL – 6, TNF-α, FBS and increasing PASI. Conclusion: Significantly increased interleukin levels and their weak positive correlation with the severity of psoriasis (PASI, BSA) in patients of chronic plaque psoriasis explains the possible role of inflammation in the causation of psoriasis. Screening may be considered in psoriatic patients with increasing duration of psoriasis, high WC, high BSA involved, high BMI, obesity, dyslipidemia and insulin resistance. Limitations: Small sample size. Conflict of Intrest: NONE. |
| first_indexed | 2024-03-11T15:45:00Z |
| format | Article |
| id | doaj.art-430f5aebde574a09b7fc8b2271876467 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-03-11T15:45:00Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-430f5aebde574a09b7fc8b22718764672023-10-26T06:34:36ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112023-01-0168437738410.4103/ijd.ijd_1015_22Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control studyVidya YadavVibhu MendirattaAparna AgrawalKavita BisherwalRitu SinghAmit K MeenaBackground: Psoriasis is a chronic, immune mediated inflammatory condition of the skin and imbalance in inflammatory mediators could result in insulin resistance, metabolic syndrome and facilitate the occurrence and progression of Non-alcoholic fatty liver disease (NAFLD). Objectives: Primary objectives: To study the frequency of NAFLD in cases of chronic plaque psoriasis and controlsTo study the interleukin levels in cases of chronic plaque psoriasis and controls. Secondary objectives: To study the BMI, lipid profile, waist circumference, FBS (fasting blood sugar), PPBS (post prandial blood sugar) and serum insulin in cases and controlsTo study the association of age, duration of psoriasis, PASI (psoriasis area severity index), BSA (body surface area) involved, BMI (body mass index), lipid profile, obesity, waist circumference, FBS (fasting blood sugar), PPBS (post prandial blood sugar) and serum insulin levels with NAFLD in patients of chronic plaque psoriasisTo correlate serum levels of IL1-β, IL6 and TNF-α with NAFLD in patients of chronic plaque psoriasis. Methods: 50 clinically diagnosed cases of chronic plaque psoriasis with age ≥ 18years, diseases duration ≥ 6 months and 30 age and sex matched controls were recruited. PASI, BSA of cases was calculated and BMI, BP, WC of all subjects was measured. Serum lipid profile, FBS, PPBS, insulin level, IL1- β, IL6, TNF- α, high frequency B-mode ultrasound, LFT and fibroscan were done in all subjects. Results: 28(56.0%) cases and 2(6.6%) controls had NAFLD with statistically significant difference. Significantly elevated WC, serum insulin, deranged lipid profile, fatty liver, transaminitis, fibroscan score, liver fibrosis, NAFLD and interleukins were found in cases vs controls. There was a significant association of NAFLD in psoriatic patients with increasing duration of psoriasis, BMI ≥23 Kg/m2, high WC, increasing BSA involved, deranged lipid profile, raised total cholesterol levels and increasing number of risk factors. Nonsignificant but positive association of NAFLD in cases was found with high levels of IL1 – β, IL – 6, TNF-α, FBS and increasing PASI. Conclusion: Significantly increased interleukin levels and their weak positive correlation with the severity of psoriasis (PASI, BSA) in patients of chronic plaque psoriasis explains the possible role of inflammation in the causation of psoriasis. Screening may be considered in psoriatic patients with increasing duration of psoriasis, high WC, high BSA involved, high BMI, obesity, dyslipidemia and insulin resistance. Limitations: Small sample size. Conflict of Intrest: NONE.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=377;epage=384;aulast=Yadavbmi (body mass index)bsa (body surface area)chronic plaque psoriasisdyslipidemiafbs (fasting blood sugar)fatty liverfibroscanil1- βil-6liver fibrosislft (liver function test)nafld (non-alcoholic fatty liver disease)pasi (psoriasis area severity index)serum insulin leveltnf- α (interleukins)th-1transaminitiswaist circumference (wc) |
| spellingShingle | Vidya Yadav Vibhu Mendiratta Aparna Agrawal Kavita Bisherwal Ritu Singh Amit K Meena Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study Indian Journal of Dermatology bmi (body mass index) bsa (body surface area) chronic plaque psoriasis dyslipidemia fbs (fasting blood sugar) fatty liver fibroscan il1- β il-6 liver fibrosis lft (liver function test) nafld (non-alcoholic fatty liver disease) pasi (psoriasis area severity index) serum insulin level tnf- α (interleukins) th-1 transaminitis waist circumference (wc) |
| title | Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study |
| title_full | Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study |
| title_fullStr | Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study |
| title_full_unstemmed | Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study |
| title_short | Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study |
| title_sort | interleukin levels and non alcoholic fatty liver disease in chronic plaque psoriasis an analytical case control study |
| topic | bmi (body mass index) bsa (body surface area) chronic plaque psoriasis dyslipidemia fbs (fasting blood sugar) fatty liver fibroscan il1- β il-6 liver fibrosis lft (liver function test) nafld (non-alcoholic fatty liver disease) pasi (psoriasis area severity index) serum insulin level tnf- α (interleukins) th-1 transaminitis waist circumference (wc) |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=377;epage=384;aulast=Yadav |
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