Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.965366/full |
| _version_ | 1828145744917299200 |
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| author | Shujuan Hu Shujuan Hu Xingxia Wan Xianhui Li Xianwang Wang |
| author_facet | Shujuan Hu Shujuan Hu Xingxia Wan Xianhui Li Xianwang Wang |
| author_sort | Shujuan Hu |
| collection | DOAJ |
| description | Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreasing the release of pyroptosis-related cytokines. However, the molecular mechanisms of aerobic exercise on pyroptosis-related diseases remain unknown. In this review, the effects of aerobic exercise on pyroptosis in endothelial cells, adipocytes and hippocampal cells, and their potential mechanisms are summarized. In endothelial cells, aerobic exercise could inhibit NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis by improving the endothelial function, while reducing vascular inflammation and oxidative stress. In adipocytes, aerobic exercise has been shown to inhibit pyroptosis by ameliorating inflammation and insulin resistance. Moreover, aerobic exercise could restrict pyroptosis by attenuating microglial activation, neuroinflammation, and amyloid-beta deposition in hippocampal cells. In summary, aerobic exercise alleviates the pyroptosis-related diseases by regulating the NLRP3 inflammation si0067naling. |
| first_indexed | 2024-04-11T20:35:57Z |
| format | Article |
| id | doaj.art-431190ec16584f6a88d8b8916cf78bee |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T20:35:57Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-431190ec16584f6a88d8b8916cf78bee2022-12-22T04:04:21ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-09-011310.3389/fphys.2022.965366965366Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasomeShujuan Hu0Shujuan Hu1Xingxia Wan2Xianhui Li3Xianwang Wang4School of Education and Physical Education, Yangtze University, Jingzhou, ChinaSchool of Physical Education and Science, Jishou University, Jishou, ChinaDepartment of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, ChinaCollege of Pharmacy, Jishou University, Jishou, ChinaDepartment of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, ChinaPyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that aerobic exercise is a good option for decreasing the release of pyroptosis-related cytokines. However, the molecular mechanisms of aerobic exercise on pyroptosis-related diseases remain unknown. In this review, the effects of aerobic exercise on pyroptosis in endothelial cells, adipocytes and hippocampal cells, and their potential mechanisms are summarized. In endothelial cells, aerobic exercise could inhibit NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis by improving the endothelial function, while reducing vascular inflammation and oxidative stress. In adipocytes, aerobic exercise has been shown to inhibit pyroptosis by ameliorating inflammation and insulin resistance. Moreover, aerobic exercise could restrict pyroptosis by attenuating microglial activation, neuroinflammation, and amyloid-beta deposition in hippocampal cells. In summary, aerobic exercise alleviates the pyroptosis-related diseases by regulating the NLRP3 inflammation si0067naling.https://www.frontiersin.org/articles/10.3389/fphys.2022.965366/fullaerobic exercisepyroptosispyroptosis-related diseasesmechanismsNLRP3 inflammasome |
| spellingShingle | Shujuan Hu Shujuan Hu Xingxia Wan Xianhui Li Xianwang Wang Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome Frontiers in Physiology aerobic exercise pyroptosis pyroptosis-related diseases mechanisms NLRP3 inflammasome |
| title | Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome |
| title_full | Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome |
| title_fullStr | Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome |
| title_full_unstemmed | Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome |
| title_short | Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome |
| title_sort | aerobic exercise alleviates pyroptosis related diseases by regulating nlrp3 inflammasome |
| topic | aerobic exercise pyroptosis pyroptosis-related diseases mechanisms NLRP3 inflammasome |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.965366/full |
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