Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners
The zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/55863 |
| _version_ | 1811235966490247168 |
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| author | Hande Tunbak Mireya Vazquez-Prada Thomas Michael Ryan Adam Raymond Kampff Elena Dreosti |
| author_facet | Hande Tunbak Mireya Vazquez-Prada Thomas Michael Ryan Adam Raymond Kampff Elena Dreosti |
| author_sort | Hande Tunbak |
| collection | DOAJ |
| description | The zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-social (loner) fish found in the normal population. These isolation-induced activity changes revealed profound disruption of neural activity in brain areas linked to social behaviour, social cue processing, and anxiety/stress. Several of the affected regions are modulated by serotonin, and we found that social preference in isolated fish could be rescued by acutely reducing serotonin levels. |
| first_indexed | 2024-04-12T12:01:10Z |
| format | Article |
| id | doaj.art-4311b1dc7d27468e974dc1a0167af573 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:01:10Z |
| publishDate | 2020-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4311b1dc7d27468e974dc1a0167af5732022-12-22T03:33:50ZengeLife Sciences Publications LtdeLife2050-084X2020-05-01910.7554/eLife.55863Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not lonersHande Tunbak0https://orcid.org/0000-0003-3180-1401Mireya Vazquez-Prada1https://orcid.org/0000-0001-7964-7576Thomas Michael Ryan2https://orcid.org/0000-0001-9469-4135Adam Raymond Kampff3https://orcid.org/0000-0003-3079-019XElena Dreosti4https://orcid.org/0000-0002-6738-7057The Wolfson Institute for Biomedical Research, University Street, University College London, London, United KingdomThe Wolfson Institute for Biomedical Research, University Street, University College London, London, United KingdomThe Wolfson Institute for Biomedical Research, University Street, University College London, London, United KingdomSainsbury Wellcome Centre, Howland Street, University College London, London, United KingdomThe Wolfson Institute for Biomedical Research, University Street, University College London, London, United KingdomThe zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-social (loner) fish found in the normal population. These isolation-induced activity changes revealed profound disruption of neural activity in brain areas linked to social behaviour, social cue processing, and anxiety/stress. Several of the affected regions are modulated by serotonin, and we found that social preference in isolated fish could be rescued by acutely reducing serotonin levels.https://elifesciences.org/articles/55863social behaviourzebrafishhypothalamusBuspironeisolationpreoptic area |
| spellingShingle | Hande Tunbak Mireya Vazquez-Prada Thomas Michael Ryan Adam Raymond Kampff Elena Dreosti Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners eLife social behaviour zebrafish hypothalamus Buspirone isolation preoptic area |
| title | Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| title_full | Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| title_fullStr | Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| title_full_unstemmed | Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| title_short | Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| title_sort | whole brain mapping of socially isolated zebrafish reveals that lonely fish are not loners |
| topic | social behaviour zebrafish hypothalamus Buspirone isolation preoptic area |
| url | https://elifesciences.org/articles/55863 |
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