IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION
Abstract. Present study defines clinical, hormonal and immunological factors allowing to predict outcomes of IVF cycles in patients with combined forms of infertility at their reproductive age. Indices of gonadotrophic ovarian stimulation in IVF cycles in patients of reproductive age with combined f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/522 |
| _version_ | 1797198079663800320 |
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| author | N. O. Motovilova I. Yu. Kogan K. A. Syssoev A. N. Buinova A. Yu. Griaznov Areg A. Totolyan |
| author_facet | N. O. Motovilova I. Yu. Kogan K. A. Syssoev A. N. Buinova A. Yu. Griaznov Areg A. Totolyan |
| author_sort | N. O. Motovilova |
| collection | DOAJ |
| description | Abstract. Present study defines clinical, hormonal and immunological factors allowing to predict outcomes of IVF cycles in patients with combined forms of infertility at their reproductive age. Indices of gonadotrophic ovarian stimulation in IVF cycles in patients of reproductive age with combined forms of infertility depend on their age and cytokine contents in follicular fluid. Effectiveness of gonadotropin-induced ovarian stimulation is inversely dependent on the patients’ age, its increase is related to increased contents of pro-inflammatory cytokines in follicular fluid and increased expression of CCR1, along with decreased expression of CCR3 chemokine receptors in endometrium. Effectiveness of gonadotropin-induced ovarian stimulation depends on concentration of cytokines in the follicular fluid, which is argued by presence of a significant direct correlation between the number of growing follicles, oocytes and local contents of IL-10, IL-15, eotaxin, MIP-1β, RANTES, TNFα, IFNγ, and GMCSF. Free testosterone levels show a positive correlation with numbers of oocytes obtained from the ovarian punctate, and CXCR2 and CCR3 expression in endometrium, as well as a negative correlation was found with IL-4 contents in follicular fluid. In patients with negative IVF cycle outcomes, levels of IL-13 in follicular fluid upon ovarian stimulation proved to be twofold higher than those in patients with successful pregnancy after IVF. Prognosis for pregnancy in a cycle of treatment in patients with combined forms of infertility of reproductive age is determined by a patients’ story, and a variety of clinical, hormonal and embryological factors which can increase predictive accuracy of the IVF outcomes. To determine a probability of successful pregnancy after IVF cycle, an appropriate prognostic index is recommended, with a sensitivity levels of 93% and specificity of 89%. |
| first_indexed | 2024-03-08T05:50:33Z |
| format | Article |
| id | doaj.art-4312ac4a72514df5a33242d818f97730 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:10Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-4312ac4a72514df5a33242d818f977302024-04-22T13:07:37ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01144-537338210.15789/1563-0625-2012-4-5-373-382519IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATIONN. O. Motovilova0I. Yu. Kogan1K. A. Syssoev2A. N. Buinova3A. Yu. Griaznov4Areg A. Totolyan5Центр Планирования Семьи Пушкинского района, Санкт-ПетербургНаучно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет им. И.П. Павлова, Санкт-ПетербургЦентр Планирования Семьи Пушкинского района, Санкт-ПетербургЦентр Планирования Семьи Пушкинского района, Санкт-ПетербургСанкт-Петербургский НИИ эпидемиологии и микробиологии имени Пастера, Санкт-ПетербургAbstract. Present study defines clinical, hormonal and immunological factors allowing to predict outcomes of IVF cycles in patients with combined forms of infertility at their reproductive age. Indices of gonadotrophic ovarian stimulation in IVF cycles in patients of reproductive age with combined forms of infertility depend on their age and cytokine contents in follicular fluid. Effectiveness of gonadotropin-induced ovarian stimulation is inversely dependent on the patients’ age, its increase is related to increased contents of pro-inflammatory cytokines in follicular fluid and increased expression of CCR1, along with decreased expression of CCR3 chemokine receptors in endometrium. Effectiveness of gonadotropin-induced ovarian stimulation depends on concentration of cytokines in the follicular fluid, which is argued by presence of a significant direct correlation between the number of growing follicles, oocytes and local contents of IL-10, IL-15, eotaxin, MIP-1β, RANTES, TNFα, IFNγ, and GMCSF. Free testosterone levels show a positive correlation with numbers of oocytes obtained from the ovarian punctate, and CXCR2 and CCR3 expression in endometrium, as well as a negative correlation was found with IL-4 contents in follicular fluid. In patients with negative IVF cycle outcomes, levels of IL-13 in follicular fluid upon ovarian stimulation proved to be twofold higher than those in patients with successful pregnancy after IVF. Prognosis for pregnancy in a cycle of treatment in patients with combined forms of infertility of reproductive age is determined by a patients’ story, and a variety of clinical, hormonal and embryological factors which can increase predictive accuracy of the IVF outcomes. To determine a probability of successful pregnancy after IVF cycle, an appropriate prognostic index is recommended, with a sensitivity levels of 93% and specificity of 89%.https://www.mimmun.ru/mimmun/article/view/522infertilitycytokinesin vitro fertilization |
| spellingShingle | N. O. Motovilova I. Yu. Kogan K. A. Syssoev A. N. Buinova A. Yu. Griaznov Areg A. Totolyan IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION Медицинская иммунология infertility cytokines in vitro fertilization |
| title | IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION |
| title_full | IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION |
| title_fullStr | IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION |
| title_full_unstemmed | IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION |
| title_short | IMPACT OF SOME CYTOKINES TO EFFICIENCY OF INFERTILITY TREATMENT BY MEANS OF IN VITRO FERTILIZATION |
| title_sort | impact of some cytokines to efficiency of infertility treatment by means of in vitro fertilization |
| topic | infertility cytokines in vitro fertilization |
| url | https://www.mimmun.ru/mimmun/article/view/522 |
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