Immunological evaluation during treatment of a case of borderline lepromatous leprosy
Background: Leprosy is a chronic granulomatous infection that affects skin and peripheral nerves. Its prevalence has declined, but is still observed mainly in poor rural areas. Case report: A male city dweller with photophobia and chronic dermatosis in the face: nodular and erythematous lesions, pus...
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016-10-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/170 |
| _version_ | 1797712048247799808 |
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| author | Blanca María Morfín-Maciel María del Carmen Jiménez-Martínez |
| author_facet | Blanca María Morfín-Maciel María del Carmen Jiménez-Martínez |
| author_sort | Blanca María Morfín-Maciel |
| collection | DOAJ |
| description | Background: Leprosy is a chronic granulomatous infection that affects skin and peripheral nerves. Its prevalence has declined, but is still observed mainly in poor rural areas.
Case report: A male city dweller with photophobia and chronic dermatosis in the face: nodular and erythematous lesions, pustules, keratitis and entropion, partial eyebrows loss, and edema on eyelids, chin, and nose bridge. The rest of the body had no lesion or lymphadenopathy. Biopsy revealed Langhans giant cell proliferation in the superficial dermis without epidermal atrophy. BAAR staining for detection were positive, no Virschow cells were observed, and Fite-Franco staining (leprosy-specific) was negative. Cutaneous tuberculosis was diagnosed. Rifampicin/isoniazid/pyrazinamide and dialysate leukocyte extract were prescribed. A month later, the swelling had decreased significantly. Polymerase chain reaction (PCR) test was positive for Mycobacterium leprae. Flow cytometry showed CD4 count normalization. Long-term treatment with rifampicin, clofazimine, and dapsone was established.
Conclusions: The host’s immune response determines the clinical features of the disease: if response is bad there will be vacuolated macrophages filled with bacilli (lepromatous leprosy). Clinical and histopathological findings help typing. |
| first_indexed | 2024-03-12T07:16:02Z |
| format | Article |
| id | doaj.art-4314e8848f544a9f90d5007cd0b730ca |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T07:16:02Z |
| publishDate | 2016-10-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-4314e8848f544a9f90d5007cd0b730ca2023-09-02T22:48:03ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902016-10-0163441341910.29262/ram.v63i4.170149Immunological evaluation during treatment of a case of borderline lepromatous leprosyBlanca María Morfín-Maciel0María del Carmen Jiménez-Martínez1Secretaría de Salud, Instituto Nacional de Pediatría. Ciudad de MéxicoUniversidad Nacional Autónoma de México, Ciudad Universitaria, Facultad de Medicina, Departamento de Bioquímica. Ciudad de MéxicoBackground: Leprosy is a chronic granulomatous infection that affects skin and peripheral nerves. Its prevalence has declined, but is still observed mainly in poor rural areas. Case report: A male city dweller with photophobia and chronic dermatosis in the face: nodular and erythematous lesions, pustules, keratitis and entropion, partial eyebrows loss, and edema on eyelids, chin, and nose bridge. The rest of the body had no lesion or lymphadenopathy. Biopsy revealed Langhans giant cell proliferation in the superficial dermis without epidermal atrophy. BAAR staining for detection were positive, no Virschow cells were observed, and Fite-Franco staining (leprosy-specific) was negative. Cutaneous tuberculosis was diagnosed. Rifampicin/isoniazid/pyrazinamide and dialysate leukocyte extract were prescribed. A month later, the swelling had decreased significantly. Polymerase chain reaction (PCR) test was positive for Mycobacterium leprae. Flow cytometry showed CD4 count normalization. Long-term treatment with rifampicin, clofazimine, and dapsone was established. Conclusions: The host’s immune response determines the clinical features of the disease: if response is bad there will be vacuolated macrophages filled with bacilli (lepromatous leprosy). Clinical and histopathological findings help typing.http://revistaalergia.mx/ojs/index.php/ram/article/view/170LepraAntifímicosExtractos dializados de leucocitosInmunomodulación |
| spellingShingle | Blanca María Morfín-Maciel María del Carmen Jiménez-Martínez Immunological evaluation during treatment of a case of borderline lepromatous leprosy Revista Alergia México Lepra Antifímicos Extractos dializados de leucocitos Inmunomodulación |
| title | Immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| title_full | Immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| title_fullStr | Immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| title_full_unstemmed | Immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| title_short | Immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| title_sort | immunological evaluation during treatment of a case of borderline lepromatous leprosy |
| topic | Lepra Antifímicos Extractos dializados de leucocitos Inmunomodulación |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/170 |
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