Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine
In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as “rods an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-08-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08916934.2020.1793135 |
| _version_ | 1827817418370580480 |
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| author | Johanna Galaski Anja C. Koop Marc Lütgehetmann Ansgar W. Lohse Christina Weiler-Normann |
| author_facet | Johanna Galaski Anja C. Koop Marc Lütgehetmann Ansgar W. Lohse Christina Weiler-Normann |
| author_sort | Johanna Galaski |
| collection | DOAJ |
| description | In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as “rods and rings” (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively associated with hepatitis C virus patients treated with pegylated interferon-α and ribavirin. However, longitudinal data for other patient groups are scarce. Here, we reviewed 276 sequential immunofluorescence results from 127 patients with autoimmune hepatitis for the presence of RR patterns. Of 102 patients exposed to drugs known to induce RR in vitro, two patients under long-term azathioprine therapy were positive for this pattern. This is the first report of anti-RR in patients with autoimmune hepatitis and in patients treated with azathioprine. |
| first_indexed | 2024-03-12T00:33:59Z |
| format | Article |
| id | doaj.art-4317b6781b724411b2aaf0a1cbf7efbd |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-12T00:33:59Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-4317b6781b724411b2aaf0a1cbf7efbd2023-09-15T10:01:09ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2020-08-0153636236510.1080/08916934.2020.17931351793135Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprineJohanna Galaski0Anja C. Koop1Marc Lütgehetmann2Ansgar W. Lohse3Christina Weiler-Normann4I. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfIn vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as “rods and rings” (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively associated with hepatitis C virus patients treated with pegylated interferon-α and ribavirin. However, longitudinal data for other patient groups are scarce. Here, we reviewed 276 sequential immunofluorescence results from 127 patients with autoimmune hepatitis for the presence of RR patterns. Of 102 patients exposed to drugs known to induce RR in vitro, two patients under long-term azathioprine therapy were positive for this pattern. This is the first report of anti-RR in patients with autoimmune hepatitis and in patients treated with azathioprine.http://dx.doi.org/10.1080/08916934.2020.1793135autoimmune hepatitisimmunofluorescencerods and ringsazathioprineautoantibodies |
| spellingShingle | Johanna Galaski Anja C. Koop Marc Lütgehetmann Ansgar W. Lohse Christina Weiler-Normann Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine Autoimmunity autoimmune hepatitis immunofluorescence rods and rings azathioprine autoantibodies |
| title | Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine |
| title_full | Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine |
| title_fullStr | Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine |
| title_full_unstemmed | Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine |
| title_short | Autoantibodies to intracellular “rods and rings” structures in two patients with autoimmune hepatitis treated with azathioprine |
| title_sort | autoantibodies to intracellular rods and rings structures in two patients with autoimmune hepatitis treated with azathioprine |
| topic | autoimmune hepatitis immunofluorescence rods and rings azathioprine autoantibodies |
| url | http://dx.doi.org/10.1080/08916934.2020.1793135 |
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