Haplopelma hainanum venom induces inflammatory skin lesions
The Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The...
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PeerJ Inc.
2020-01-01
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| Online Access: | https://peerj.com/articles/8264.pdf |
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| author | Zhili Deng Yaling Wang Wei Shi Lei Zhou San Xu Ji Li Yiya Zhang |
| author_facet | Zhili Deng Yaling Wang Wei Shi Lei Zhou San Xu Ji Li Yiya Zhang |
| author_sort | Zhili Deng |
| collection | DOAJ |
| description | The Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The pathological consequences of envenomation by H. hainanum remain unclear. In this study, we investigated the effects and mechanisms of H. hainanum envenomation in mice. We showed that the venom induced slight swelling, intense inflammatory response, and increased the microvascular density in mice skin. Moreover, we found that 50 µg/ml of the spider’s venom induced IL-1β expression in both HaCaT cells and fibroblast cells, but repressed CXCL10 expression in fibroblasts. The venom significantly induced cell senescence and repressed cell proliferation and migration in both HaCaT cells and fibroblast cells. Finally, we examined the expression of Nav channel in HaCaT and fibroblast cells and found that H. hainanum venom effectively inhibited Na+ currents in HaCaT cells. Our study calls for further investigation of the pathological consequences and potential mechanisms of H. hainanum envenomation. This information might assist in the development of suitable therapy. |
| first_indexed | 2024-03-09T06:28:42Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:28:42Z |
| publishDate | 2020-01-01 |
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| spelling | doaj.art-431a81b2468349269adc89350ac50e1a2023-12-03T11:10:37ZengPeerJ Inc.PeerJ2167-83592020-01-018e826410.7717/peerj.8264Haplopelma hainanum venom induces inflammatory skin lesionsZhili Deng0Yaling Wang1Wei Shi2Lei Zhou3San Xu4Ji Li5Yiya Zhang6Department of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaThe Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The pathological consequences of envenomation by H. hainanum remain unclear. In this study, we investigated the effects and mechanisms of H. hainanum envenomation in mice. We showed that the venom induced slight swelling, intense inflammatory response, and increased the microvascular density in mice skin. Moreover, we found that 50 µg/ml of the spider’s venom induced IL-1β expression in both HaCaT cells and fibroblast cells, but repressed CXCL10 expression in fibroblasts. The venom significantly induced cell senescence and repressed cell proliferation and migration in both HaCaT cells and fibroblast cells. Finally, we examined the expression of Nav channel in HaCaT and fibroblast cells and found that H. hainanum venom effectively inhibited Na+ currents in HaCaT cells. Our study calls for further investigation of the pathological consequences and potential mechanisms of H. hainanum envenomation. This information might assist in the development of suitable therapy.https://peerj.com/articles/8264.pdfH. hainanum venomEnvenomationInflammationRevascularization |
| spellingShingle | Zhili Deng Yaling Wang Wei Shi Lei Zhou San Xu Ji Li Yiya Zhang Haplopelma hainanum venom induces inflammatory skin lesions PeerJ H. hainanum venom Envenomation Inflammation Revascularization |
| title | Haplopelma hainanum venom induces inflammatory skin lesions |
| title_full | Haplopelma hainanum venom induces inflammatory skin lesions |
| title_fullStr | Haplopelma hainanum venom induces inflammatory skin lesions |
| title_full_unstemmed | Haplopelma hainanum venom induces inflammatory skin lesions |
| title_short | Haplopelma hainanum venom induces inflammatory skin lesions |
| title_sort | haplopelma hainanum venom induces inflammatory skin lesions |
| topic | H. hainanum venom Envenomation Inflammation Revascularization |
| url | https://peerj.com/articles/8264.pdf |
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