Fitness Trade-Offs in Phage Cocktail-Resistant Salmonella enterica Serovar Enteritidis Results in Increased Antibiotic Susceptibility and Reduced Virulence

Fitness Trade-Offs in Phage Cocktail-Resistant Salmonella enterica Serovar Enteritidis Results in Increased Antibiotic Susceptibility and Reduced Virulence

ABSTRACT The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage therapy. Phage cocktails have been considered one approach to mitigate this issue. However, the synergistic effect of randomly selected phages in the cocktails is ambiguous. Here, we rationally designed...

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Bibliographic Details
Main Authors: Dongyang Gao, Hongyue Ji, Linkang Wang, Xinxin Li, Dayue Hu, Junna Zhao, Shuang Wang, Pan Tao, Xiangmin Li, Ping Qian
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Salmonella Enteritidis
phage therapy
phage cocktails
phage receptors
fitness costs
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02914-22

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