B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expan...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37205-5 |
| _version_ | 1827983322886701056 |
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| author | Liat Stoler-Barak Ethan Harris Ayelet Peres Hadas Hezroni Mirela Kuka Pietro Di Lucia Amalie Grenov Neta Gurwicz Meital Kupervaser Bon Ham Yip Matteo Iannacone Gur Yaari John D. Crispino Ziv Shulman |
| author_facet | Liat Stoler-Barak Ethan Harris Ayelet Peres Hadas Hezroni Mirela Kuka Pietro Di Lucia Amalie Grenov Neta Gurwicz Meital Kupervaser Bon Ham Yip Matteo Iannacone Gur Yaari John D. Crispino Ziv Shulman |
| author_sort | Liat Stoler-Barak |
| collection | DOAJ |
| description | Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expansion. |
| first_indexed | 2024-04-09T22:46:49Z |
| format | Article |
| id | doaj.art-431be3cd018542aa832ba2a735ae482b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:46:49Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-431be3cd018542aa832ba2a735ae482b2023-03-22T11:48:06ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-37205-5B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylationLiat Stoler-Barak0Ethan Harris1Ayelet Peres2Hadas Hezroni3Mirela Kuka4Pietro Di Lucia5Amalie Grenov6Neta Gurwicz7Meital Kupervaser8Bon Ham Yip9Matteo Iannacone10Gur Yaari11John D. Crispino12Ziv Shulman13Department of Systems Immunology, Weizmann Institute of ScienceDepartment of Hematology, St. Jude Children’s Research HospitalFaculty of Engineering, Bar Ilan UniversityDepartment of Systems Immunology, Weizmann Institute of ScienceVita-Salute San Raffaele University and Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele University and Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific InstituteDepartment of Systems Immunology, Weizmann Institute of ScienceDepartment of Systems Immunology, Weizmann Institute of ScienceDe Botton Institute for Proteomics, Grand Israel National Center for Personalized Medicine, Weizmann Institute of ScienceDepartment of Hematology, St. Jude Children’s Research HospitalVita-Salute San Raffaele University and Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific InstituteFaculty of Engineering, Bar Ilan UniversityDepartment of Hematology, St. Jude Children’s Research HospitalDepartment of Systems Immunology, Weizmann Institute of ScienceClass switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expansion.https://doi.org/10.1038/s41467-023-37205-5 |
| spellingShingle | Liat Stoler-Barak Ethan Harris Ayelet Peres Hadas Hezroni Mirela Kuka Pietro Di Lucia Amalie Grenov Neta Gurwicz Meital Kupervaser Bon Ham Yip Matteo Iannacone Gur Yaari John D. Crispino Ziv Shulman B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation Nature Communications |
| title | B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation |
| title_full | B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation |
| title_fullStr | B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation |
| title_full_unstemmed | B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation |
| title_short | B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation |
| title_sort | b cell class switch recombination is regulated by dyrk1a through msh6 phosphorylation |
| url | https://doi.org/10.1038/s41467-023-37205-5 |
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