Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
ABSTRACT Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior. Level of phenylalanine and serotonin were found high in hyperactive children...
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Format: | Article |
Language: | English |
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Diponegoro University
2017-12-01
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Series: | Journal of Biomedicine and Translational Research |
Subjects: | |
Online Access: | https://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744 |
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author | Puspito Arum Dahlia Indah Amareta Faridlotul Zannah |
author_facet | Puspito Arum Dahlia Indah Amareta Faridlotul Zannah |
author_sort | Puspito Arum |
collection | DOAJ |
description | ABSTRACT
Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior. Level of phenylalanine and serotonin were found high in hyperactive children with autism. Level phenylalanine in the brain shows that it is not changed into tyrosine so dopamine can not be form. Serotonin derived from an amino acid tryptophan.
Objective: To understand the association between phenylalanine and tryptophan intake to hyperactivity of children with autism.
Methods: A survey analytic research with cross sectional approach involving 20 subjects. Phenylalanine and tryptophan intake data was collected by Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ), and hyperactivity disorder of children with autism was measured based on DSM-IV guidelines.
Results: Eight (40%) children had low hyperactivity, 9 (45%) children had moderate hyperactivity, 2 (10%) children had severe hyperactivity, and 1 (5%) child had very severe hyperactivity. Mean phenylalanine intake was 4899.74mg (±1543.42) with maximum and minimum intake respectively 7735.42mg and 1843.88mg. Tryptophan intake was 1153.91mg (±384.99) with maximum and minimum intake respectively 1953.89mg and 367.69mg. There was significant association between phenylalanine intake (p=0,034; r=0,477) and tryptophan intake and hyperactivity (p=0,026; r=0,492).
Conclusion: There is an association between intakes of amino acid phenylalanine and amino acid tryptophan with hyperactivity of autistic children |
first_indexed | 2024-12-22T17:26:18Z |
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id | doaj.art-431d69159b7545d6b7d9a25a4ff28c76 |
institution | Directory Open Access Journal |
issn | 2503-2178 |
language | English |
last_indexed | 2024-12-22T17:26:18Z |
publishDate | 2017-12-01 |
publisher | Diponegoro University |
record_format | Article |
series | Journal of Biomedicine and Translational Research |
spelling | doaj.art-431d69159b7545d6b7d9a25a4ff28c762022-12-21T18:18:42ZengDiponegoro UniversityJournal of Biomedicine and Translational Research2503-21782017-12-0132343610.14710/jbtr.v3i2.17441177Phenylalanine and Tryptophan Intake of Hyperactive Children with AutismPuspito Arum0Dahlia Indah Amareta1Faridlotul Zannah2Politeknik Negeri JemberPoliteknik Negeri JemberPoliteknik Negeri JemberABSTRACT Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior. Level of phenylalanine and serotonin were found high in hyperactive children with autism. Level phenylalanine in the brain shows that it is not changed into tyrosine so dopamine can not be form. Serotonin derived from an amino acid tryptophan. Objective: To understand the association between phenylalanine and tryptophan intake to hyperactivity of children with autism. Methods: A survey analytic research with cross sectional approach involving 20 subjects. Phenylalanine and tryptophan intake data was collected by Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ), and hyperactivity disorder of children with autism was measured based on DSM-IV guidelines. Results: Eight (40%) children had low hyperactivity, 9 (45%) children had moderate hyperactivity, 2 (10%) children had severe hyperactivity, and 1 (5%) child had very severe hyperactivity. Mean phenylalanine intake was 4899.74mg (±1543.42) with maximum and minimum intake respectively 7735.42mg and 1843.88mg. Tryptophan intake was 1153.91mg (±384.99) with maximum and minimum intake respectively 1953.89mg and 367.69mg. There was significant association between phenylalanine intake (p=0,034; r=0,477) and tryptophan intake and hyperactivity (p=0,026; r=0,492). Conclusion: There is an association between intakes of amino acid phenylalanine and amino acid tryptophan with hyperactivity of autistic childrenhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744autismdopaminehyperactivephenylalanineserotonintryptophan |
spellingShingle | Puspito Arum Dahlia Indah Amareta Faridlotul Zannah Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism Journal of Biomedicine and Translational Research autism dopamine hyperactive phenylalanine serotonin tryptophan |
title | Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism |
title_full | Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism |
title_fullStr | Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism |
title_full_unstemmed | Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism |
title_short | Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism |
title_sort | phenylalanine and tryptophan intake of hyperactive children with autism |
topic | autism dopamine hyperactive phenylalanine serotonin tryptophan |
url | https://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744 |
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