Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism

ABSTRACT Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.  Level of phenylalanine and serotonin were found high in hyperactive children...

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Main Authors: Puspito Arum, Dahlia Indah Amareta, Faridlotul Zannah
Format: Article
Language:English
Published: Diponegoro University 2017-12-01
Series:Journal of Biomedicine and Translational Research
Subjects:
Online Access:https://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744
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author Puspito Arum
Dahlia Indah Amareta
Faridlotul Zannah
author_facet Puspito Arum
Dahlia Indah Amareta
Faridlotul Zannah
author_sort Puspito Arum
collection DOAJ
description ABSTRACT Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.  Level of phenylalanine and serotonin were found high in hyperactive children with autism. Level phenylalanine in the brain shows that it is not changed into tyrosine so dopamine can not be form. Serotonin derived from an amino acid tryptophan. Objective: To understand the association between phenylalanine and tryptophan intake to hyperactivity of  children with autism. Methods: A survey analytic research with cross sectional approach involving 20 subjects. Phenylalanine and tryptophan intake data was collected by Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ), and hyperactivity disorder of children with autism was measured based on DSM-IV guidelines. Results: Eight (40%) children had low hyperactivity, 9 (45%) children had moderate hyperactivity, 2 (10%) children had severe hyperactivity, and 1 (5%) child had very severe hyperactivity. Mean phenylalanine intake was 4899.74mg (±1543.42) with maximum and minimum intake respectively 7735.42mg and 1843.88mg. Tryptophan intake was 1153.91mg (±384.99) with maximum and minimum intake respectively 1953.89mg and 367.69mg. There was significant association between phenylalanine intake (p=0,034; r=0,477) and tryptophan intake and hyperactivity (p=0,026; r=0,492). Conclusion: There is an association between intakes of amino acid phenylalanine and amino acid tryptophan with hyperactivity of autistic children
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spelling doaj.art-431d69159b7545d6b7d9a25a4ff28c762022-12-21T18:18:42ZengDiponegoro UniversityJournal of Biomedicine and Translational Research2503-21782017-12-0132343610.14710/jbtr.v3i2.17441177Phenylalanine and Tryptophan Intake of Hyperactive Children with AutismPuspito Arum0Dahlia Indah Amareta1Faridlotul Zannah2Politeknik Negeri JemberPoliteknik Negeri JemberPoliteknik Negeri JemberABSTRACT Background: Hyperactive is behavior which demonstrates the attitude of more energy than normal behavior. Level of neurotransmitter dopamine and serotonin in the body may be the factor of this disorder behavior.  Level of phenylalanine and serotonin were found high in hyperactive children with autism. Level phenylalanine in the brain shows that it is not changed into tyrosine so dopamine can not be form. Serotonin derived from an amino acid tryptophan. Objective: To understand the association between phenylalanine and tryptophan intake to hyperactivity of  children with autism. Methods: A survey analytic research with cross sectional approach involving 20 subjects. Phenylalanine and tryptophan intake data was collected by Semi Quantitative-Food Frequency Questionnaire (SQ-FFQ), and hyperactivity disorder of children with autism was measured based on DSM-IV guidelines. Results: Eight (40%) children had low hyperactivity, 9 (45%) children had moderate hyperactivity, 2 (10%) children had severe hyperactivity, and 1 (5%) child had very severe hyperactivity. Mean phenylalanine intake was 4899.74mg (±1543.42) with maximum and minimum intake respectively 7735.42mg and 1843.88mg. Tryptophan intake was 1153.91mg (±384.99) with maximum and minimum intake respectively 1953.89mg and 367.69mg. There was significant association between phenylalanine intake (p=0,034; r=0,477) and tryptophan intake and hyperactivity (p=0,026; r=0,492). Conclusion: There is an association between intakes of amino acid phenylalanine and amino acid tryptophan with hyperactivity of autistic childrenhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744autismdopaminehyperactivephenylalanineserotonintryptophan
spellingShingle Puspito Arum
Dahlia Indah Amareta
Faridlotul Zannah
Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
Journal of Biomedicine and Translational Research
autism
dopamine
hyperactive
phenylalanine
serotonin
tryptophan
title Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
title_full Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
title_fullStr Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
title_full_unstemmed Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
title_short Phenylalanine and Tryptophan Intake of Hyperactive Children with Autism
title_sort phenylalanine and tryptophan intake of hyperactive children with autism
topic autism
dopamine
hyperactive
phenylalanine
serotonin
tryptophan
url https://ejournal2.undip.ac.id/index.php/jbtr/article/view/1744
work_keys_str_mv AT puspitoarum phenylalanineandtryptophanintakeofhyperactivechildrenwithautism
AT dahliaindahamareta phenylalanineandtryptophanintakeofhyperactivechildrenwithautism
AT faridlotulzannah phenylalanineandtryptophanintakeofhyperactivechildrenwithautism