Research Progress of Radiation-indnced Heart Disease
Radiotherapy(RT) improves the survival of many cancer patients, but there are some adverse effects of radiation. One of them is radiation-induced heart disease(RIHD). In case of chest irradiation, RIHD can affect the heart, blood vessels and lungs, with consequent tissue remodelation. This complex p...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2018-11-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0893.htm |
| _version_ | 1818066645610921984 |
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| author | LIU Zhifei WANG Yingjie |
| author_facet | LIU Zhifei WANG Yingjie |
| author_sort | LIU Zhifei |
| collection | DOAJ |
| description | Radiotherapy(RT) improves the survival of many cancer patients, but there are some adverse effects of radiation. One of them is radiation-induced heart disease(RIHD). In case of chest irradiation, RIHD can affect the heart, blood vessels and lungs, with consequent tissue remodelation. This complex process is composed of a large number of interacting molecular signals, including cytokines, chemokines and growth factors. Inflammation, endothelial cell dysfunction, thrombogenesis, organ dysfunction and ultimate failing of the heart occur as the pathological entity-RIHD which is associated with radiation therapy for mediastinal lymphoma, breast, lung and oesophageal cancers, etc. And is the major source of morbidity and mortality. The long latent period is the reason why RHID is not extensively studied. With the prolonged survival of cancer patients, RIHD is growing concerned, especially in younger patients. In this review article, we discuss the pathogenesis, the type of injury and influencing factors. |
| first_indexed | 2024-12-10T15:11:05Z |
| format | Article |
| id | doaj.art-431d7f916b844f079c06f52dbd1644d5 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-10T15:11:05Z |
| publishDate | 2018-11-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-431d7f916b844f079c06f52dbd1644d52022-12-22T01:43:55ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-11-01451185285710.3971/j.issn.1000-8578.2018.18.08938578.2018.18.0893Research Progress of Radiation-indnced Heart DiseaseLIU Zhifei0WANG Yingjie1Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, ChinaDepartment of Radiation Oncology, Air Force General Hospital, Beijing 100142, ChinaRadiotherapy(RT) improves the survival of many cancer patients, but there are some adverse effects of radiation. One of them is radiation-induced heart disease(RIHD). In case of chest irradiation, RIHD can affect the heart, blood vessels and lungs, with consequent tissue remodelation. This complex process is composed of a large number of interacting molecular signals, including cytokines, chemokines and growth factors. Inflammation, endothelial cell dysfunction, thrombogenesis, organ dysfunction and ultimate failing of the heart occur as the pathological entity-RIHD which is associated with radiation therapy for mediastinal lymphoma, breast, lung and oesophageal cancers, etc. And is the major source of morbidity and mortality. The long latent period is the reason why RHID is not extensively studied. With the prolonged survival of cancer patients, RIHD is growing concerned, especially in younger patients. In this review article, we discuss the pathogenesis, the type of injury and influencing factors.http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0893.htmradiotherapyradiation-induced heart disease(rihd)pathogenesistoxic type |
| spellingShingle | LIU Zhifei WANG Yingjie Research Progress of Radiation-indnced Heart Disease Zhongliu Fangzhi Yanjiu radiotherapy radiation-induced heart disease(rihd) pathogenesis toxic type |
| title | Research Progress of Radiation-indnced Heart Disease |
| title_full | Research Progress of Radiation-indnced Heart Disease |
| title_fullStr | Research Progress of Radiation-indnced Heart Disease |
| title_full_unstemmed | Research Progress of Radiation-indnced Heart Disease |
| title_short | Research Progress of Radiation-indnced Heart Disease |
| title_sort | research progress of radiation indnced heart disease |
| topic | radiotherapy radiation-induced heart disease(rihd) pathogenesis toxic type |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0893.htm |
| work_keys_str_mv | AT liuzhifei researchprogressofradiationindncedheartdisease AT wangyingjie researchprogressofradiationindncedheartdisease |