Liquid biopsy in NSCLC: a new challenge in radiation therapy
Lung cancer is the most common cancer and the leading cause of cancer mortality worldwide. To date, tissue biopsy has been the gold standard for the diagnosis and the identification of specific molecular mutations, to guide choice of therapy. However, this procedure has several limitations. Liquid b...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2021-04-01
|
| Series: | Exploration of Targeted Anti-tumor Therapy |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/etat/Article/100238 |
| _version_ | 1818647943930970112 |
|---|---|
| author | Annarita Perillo Mohamed Vincenzo Agbaje Olufemi Jacopo De Robbio Rossella Margherita Mancuso Anna Roscigno Maddalena Tirozzi Ida Rosalia Scognamiglio |
| author_facet | Annarita Perillo Mohamed Vincenzo Agbaje Olufemi Jacopo De Robbio Rossella Margherita Mancuso Anna Roscigno Maddalena Tirozzi Ida Rosalia Scognamiglio |
| author_sort | Annarita Perillo |
| collection | DOAJ |
| description | Lung cancer is the most common cancer and the leading cause of cancer mortality worldwide. To date, tissue biopsy has been the gold standard for the diagnosis and the identification of specific molecular mutations, to guide choice of therapy. However, this procedure has several limitations. Liquid biopsy could represent a solution to the intrinsic limits of traditional biopsy. It can detect cancer markers such as circulating tumor DNA or RNA (ctDNA, ctRNA), and circulating tumor cells, in plasma, serum or other biological fluids. This procedure is minimally invasive, reproducible and can be used repeatedly. The main clinical applications of liquid biopsy in non-small cell lung cancer (NSCLC) patients are the early diagnosis, stratification of the risk of relapse, identification of mutations to guide application of targeted therapy and the evaluation of the minimum residual disease. In this review, the current role of liquid biopsy and associated markers in the management of NSCLC patients was analyzed, with emphasis on ctDNA and CTCs, and radiotherapy. |
| first_indexed | 2024-12-17T01:10:34Z |
| format | Article |
| id | doaj.art-431f71ac6c5a4617a897a4a3ff4825e1 |
| institution | Directory Open Access Journal |
| issn | 2692-3114 |
| language | English |
| last_indexed | 2024-12-17T01:10:34Z |
| publishDate | 2021-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Targeted Anti-tumor Therapy |
| spelling | doaj.art-431f71ac6c5a4617a897a4a3ff4825e12022-12-21T22:09:08ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142021-04-012210.37349/etat.2021.00038Liquid biopsy in NSCLC: a new challenge in radiation therapyAnnarita Perillo0https://orcid.org/0000-0002-2504-6668Mohamed Vincenzo Agbaje Olufemi1https://orcid.org/0000-0001-9411-7186Jacopo De Robbio2https://orcid.org/0000-0003-0562-2434Rossella Margherita Mancuso3https://orcid.org/0000-0002-1780-449XAnna Roscigno4https://orcid.org/0000-0002-6457-3794Maddalena Tirozzi5https://orcid.org/0000-0002-8867-3626Ida Rosalia Scognamiglio6https://orcid.org/0000-0002-6947-4461Department of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyDepartment of Advanced Biomedical Sciences, University “Federico II” School of Medicine, Via Sergio Pansini 5, 80131 Napoli, ItalyLung cancer is the most common cancer and the leading cause of cancer mortality worldwide. To date, tissue biopsy has been the gold standard for the diagnosis and the identification of specific molecular mutations, to guide choice of therapy. However, this procedure has several limitations. Liquid biopsy could represent a solution to the intrinsic limits of traditional biopsy. It can detect cancer markers such as circulating tumor DNA or RNA (ctDNA, ctRNA), and circulating tumor cells, in plasma, serum or other biological fluids. This procedure is minimally invasive, reproducible and can be used repeatedly. The main clinical applications of liquid biopsy in non-small cell lung cancer (NSCLC) patients are the early diagnosis, stratification of the risk of relapse, identification of mutations to guide application of targeted therapy and the evaluation of the minimum residual disease. In this review, the current role of liquid biopsy and associated markers in the management of NSCLC patients was analyzed, with emphasis on ctDNA and CTCs, and radiotherapy.https://www.explorationpub.com/Journals/etat/Article/100238lung cancerliquid biopsypersonalized therapyradiotherapytissue biopsy |
| spellingShingle | Annarita Perillo Mohamed Vincenzo Agbaje Olufemi Jacopo De Robbio Rossella Margherita Mancuso Anna Roscigno Maddalena Tirozzi Ida Rosalia Scognamiglio Liquid biopsy in NSCLC: a new challenge in radiation therapy Exploration of Targeted Anti-tumor Therapy lung cancer liquid biopsy personalized therapy radiotherapy tissue biopsy |
| title | Liquid biopsy in NSCLC: a new challenge in radiation therapy |
| title_full | Liquid biopsy in NSCLC: a new challenge in radiation therapy |
| title_fullStr | Liquid biopsy in NSCLC: a new challenge in radiation therapy |
| title_full_unstemmed | Liquid biopsy in NSCLC: a new challenge in radiation therapy |
| title_short | Liquid biopsy in NSCLC: a new challenge in radiation therapy |
| title_sort | liquid biopsy in nsclc a new challenge in radiation therapy |
| topic | lung cancer liquid biopsy personalized therapy radiotherapy tissue biopsy |
| url | https://www.explorationpub.com/Journals/etat/Article/100238 |
| work_keys_str_mv | AT annaritaperillo liquidbiopsyinnsclcanewchallengeinradiationtherapy AT mohamedvincenzoagbajeolufemi liquidbiopsyinnsclcanewchallengeinradiationtherapy AT jacopoderobbio liquidbiopsyinnsclcanewchallengeinradiationtherapy AT rossellamargheritamancuso liquidbiopsyinnsclcanewchallengeinradiationtherapy AT annaroscigno liquidbiopsyinnsclcanewchallengeinradiationtherapy AT maddalenatirozzi liquidbiopsyinnsclcanewchallengeinradiationtherapy AT idarosaliascognamiglio liquidbiopsyinnsclcanewchallengeinradiationtherapy |