Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

Summary: Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significa...

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Bibliographic Details
Main Authors: Yan Qiu, Yuanyuan Yang, Yuda Wei, Xiaojian Liu, Zhuanghui Feng, Xuwen Zeng, Yanhao Chen, Yan Liu, Yongxu Zhao, Lanlan Chen, Lijun Luo, Qiurong Ding
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Human Metabolism
Molecular Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306386

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