Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients
BackgroundSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a novel medication for treating type 2 diabetes (T2DM), which have the pleiotropic effect of weight reduction. This study aimed to evaluate clinical and biochemical predictors of effective weight reduction in T2DM patients who use vari...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1251798/full |
| _version_ | 1827375258582122496 |
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| author | Pojsakorn Danpanichkul Worapaka Manosroi Worapaka Manosroi Tharadon Nilsirisuk Theetouch Tosukhowong |
| author_facet | Pojsakorn Danpanichkul Worapaka Manosroi Worapaka Manosroi Tharadon Nilsirisuk Theetouch Tosukhowong |
| author_sort | Pojsakorn Danpanichkul |
| collection | DOAJ |
| description | BackgroundSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a novel medication for treating type 2 diabetes (T2DM), which have the pleiotropic effect of weight reduction. This study aimed to evaluate clinical and biochemical predictors of effective weight reduction in T2DM patients who use various types of SGLT2i.Materials and methodsA retrospective study was conducted with 289 adults diagnosed with T2DM who were first prescribed SGLT2i either as monotherapy or add-on therapy. The primary outcome was the identification of clinical and biochemical factors that can potentially induce meaningful weight reduction (>3% in 1 year) in T2DM patients while using SGLT2 inhibitors. The relationship between predictors and significant weight loss was assessed using logistic regression analysis, including adjustment for confounding factors. Results are presented as odds ratios (ORs) with a 95% confidence interval (CI).ResultsAmong the 289 patients, 45.6% had significant weight loss following SGLT2i use. The significant clinical predictors were age >70 years old (OR 3.26, 95% CI 1.39-7.6, p=0.006), body mass index >25 kg/m2 (OR 1.02, 95% CI 1.01-1.05, p=0.049), and the use of sulfonylureas (OR 2.41, 95% CI 1.15-5.09, p=0.020). Additionally, the use of HCTZ showed significantly decreased odds of weight loss (OR 0.35, 95% CI 0.13-0.96, p=0.043).ConclusionThis research highlights multiple clinical factors that potentially can predict meaningful weight loss in patients with T2DM who are treated with SGLT2i. These findings could facilitate the identification of patients who might benefit from the weight loss effects of SGLT2i. |
| first_indexed | 2024-03-08T11:48:18Z |
| format | Article |
| id | doaj.art-4322882d3c42415eaa6a43897b39fe58 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T11:48:18Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4322882d3c42415eaa6a43897b39fe582024-01-24T15:59:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12517981251798Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patientsPojsakorn Danpanichkul0Worapaka Manosroi1Worapaka Manosroi2Tharadon Nilsirisuk3Theetouch Tosukhowong4Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Endocrinology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, ThailandClinical Epidemiology and Clinical Statistics Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandFaculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandBackgroundSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a novel medication for treating type 2 diabetes (T2DM), which have the pleiotropic effect of weight reduction. This study aimed to evaluate clinical and biochemical predictors of effective weight reduction in T2DM patients who use various types of SGLT2i.Materials and methodsA retrospective study was conducted with 289 adults diagnosed with T2DM who were first prescribed SGLT2i either as monotherapy or add-on therapy. The primary outcome was the identification of clinical and biochemical factors that can potentially induce meaningful weight reduction (>3% in 1 year) in T2DM patients while using SGLT2 inhibitors. The relationship between predictors and significant weight loss was assessed using logistic regression analysis, including adjustment for confounding factors. Results are presented as odds ratios (ORs) with a 95% confidence interval (CI).ResultsAmong the 289 patients, 45.6% had significant weight loss following SGLT2i use. The significant clinical predictors were age >70 years old (OR 3.26, 95% CI 1.39-7.6, p=0.006), body mass index >25 kg/m2 (OR 1.02, 95% CI 1.01-1.05, p=0.049), and the use of sulfonylureas (OR 2.41, 95% CI 1.15-5.09, p=0.020). Additionally, the use of HCTZ showed significantly decreased odds of weight loss (OR 0.35, 95% CI 0.13-0.96, p=0.043).ConclusionThis research highlights multiple clinical factors that potentially can predict meaningful weight loss in patients with T2DM who are treated with SGLT2i. These findings could facilitate the identification of patients who might benefit from the weight loss effects of SGLT2i.https://www.frontiersin.org/articles/10.3389/fendo.2023.1251798/fullSGLT2 inhibitorsweight reductiondiabetes mellitus type 2weight lossdiabetes |
| spellingShingle | Pojsakorn Danpanichkul Worapaka Manosroi Worapaka Manosroi Tharadon Nilsirisuk Theetouch Tosukhowong Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients Frontiers in Endocrinology SGLT2 inhibitors weight reduction diabetes mellitus type 2 weight loss diabetes |
| title | Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients |
| title_full | Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients |
| title_fullStr | Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients |
| title_full_unstemmed | Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients |
| title_short | Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients |
| title_sort | predictors of weight reduction effectiveness of sglt2 inhibitors in diabetes mellitus type 2 patients |
| topic | SGLT2 inhibitors weight reduction diabetes mellitus type 2 weight loss diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1251798/full |
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