Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip
Abstract Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Online Access: | https://doi.org/10.1186/s13018-021-02784-w |
| _version_ | 1828739228648865792 |
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| author | Semih Ayanoğlu Haluk Çabuk Fatmagül Kuşku Çabuk Kubilay Beng Timur Yildirim Süheyla Uyar Bozkurt |
| author_facet | Semih Ayanoğlu Haluk Çabuk Fatmagül Kuşku Çabuk Kubilay Beng Timur Yildirim Süheyla Uyar Bozkurt |
| author_sort | Semih Ayanoğlu |
| collection | DOAJ |
| description | Abstract Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH. Methods We identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score. Results The mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found. Conclusion As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH. Level of evidence Level 2, Prospective comparative study. |
| first_indexed | 2024-04-13T00:18:52Z |
| format | Article |
| id | doaj.art-43234de067c6423aa2cbb3ed28ead135 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T00:18:52Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-43234de067c6423aa2cbb3ed28ead1352022-12-22T03:10:50ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-10-011611610.1186/s13018-021-02784-wGreater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hipSemih Ayanoğlu0Haluk Çabuk1Fatmagül Kuşku Çabuk2Kubilay Beng3Timur Yildirim4Süheyla Uyar Bozkurt5Orthopedics and Traumatology Department, İstanbul Altınbaş UniversityOrthopedics and Traumatology Department, İstinye UniversityDepartment of Medical Pathology, İstanbul Bakırköy Dr Sadi Konuk Training and Research HospitalBaltalimani Bone Diseases Training and Research Center, University of Health Sciences TurkeyBaltalimani Bone Diseases Training and Research Center, University of Health Sciences TurkeyDepartment of Medical Pathology, Medical School, Marmara UniversityAbstract Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH. Methods We identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score. Results The mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found. Conclusion As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH. Level of evidence Level 2, Prospective comparative study.https://doi.org/10.1186/s13018-021-02784-w |
| spellingShingle | Semih Ayanoğlu Haluk Çabuk Fatmagül Kuşku Çabuk Kubilay Beng Timur Yildirim Süheyla Uyar Bozkurt Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip Journal of Orthopaedic Surgery and Research |
| title | Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| title_full | Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| title_fullStr | Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| title_full_unstemmed | Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| title_short | Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| title_sort | greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip |
| url | https://doi.org/10.1186/s13018-021-02784-w |
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