Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model
Abstract: Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Lambung Mangkurat
2023-02-01
|
| Series: | Berkala Kedokteran |
| Subjects: | |
| Online Access: | https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15703 |
| _version_ | 1827352425677193216 |
|---|---|
| author | Amy Nindia Carabelly Beta Widya Oktiani Nurashfia Nurashfia Maharani Laillyza Apriasari Dewi Puspitasari |
| author_facet | Amy Nindia Carabelly Beta Widya Oktiani Nurashfia Nurashfia Maharani Laillyza Apriasari Dewi Puspitasari |
| author_sort | Amy Nindia Carabelly |
| collection | DOAJ |
| description | Abstract:
Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models. |
| first_indexed | 2024-03-08T03:05:44Z |
| format | Article |
| id | doaj.art-432576ff6ef24c278a4278eba1955f91 |
| institution | Directory Open Access Journal |
| issn | 1412-0550 2548-5660 |
| language | English |
| last_indexed | 2024-03-08T03:05:44Z |
| publishDate | 2023-02-01 |
| publisher | Universitas Lambung Mangkurat |
| record_format | Article |
| series | Berkala Kedokteran |
| spelling | doaj.art-432576ff6ef24c278a4278eba1955f912024-02-13T09:27:32ZengUniversitas Lambung MangkuratBerkala Kedokteran1412-05502548-56602023-02-011911810.20527/jbk.v19i1.157038360Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat ModelAmy Nindia Carabelly0Beta Widya Oktiani1Nurashfia Nurashfia2Maharani Laillyza Apriasari3Dewi Puspitasari4Lambung Mangkurat UniversityLambung Mangkurat UniversityLambung Mangkurat UniversityLambung Mangkurat UniversityLambung Mangkurat UniversityAbstract: Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models.https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15703acute toxicity testerythrocytesdiabetes melitushemoglobintoman fish |
| spellingShingle | Amy Nindia Carabelly Beta Widya Oktiani Nurashfia Nurashfia Maharani Laillyza Apriasari Dewi Puspitasari Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model Berkala Kedokteran acute toxicity test erythrocytes diabetes melitus hemoglobin toman fish |
| title | Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model |
| title_full | Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model |
| title_fullStr | Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model |
| title_full_unstemmed | Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model |
| title_short | Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model |
| title_sort | acute toxicity test of toman fish extract on erythrocyte number and hemoglobin level in normal and diabetic wistar rat model |
| topic | acute toxicity test erythrocytes diabetes melitus hemoglobin toman fish |
| url | https://ppjp.ulm.ac.id/journal/index.php/jbk/article/view/15703 |
| work_keys_str_mv | AT amynindiacarabelly acutetoxicitytestoftomanfishextractonerythrocytenumberandhemoglobinlevelinnormalanddiabeticwistarratmodel AT betawidyaoktiani acutetoxicitytestoftomanfishextractonerythrocytenumberandhemoglobinlevelinnormalanddiabeticwistarratmodel AT nurashfianurashfia acutetoxicitytestoftomanfishextractonerythrocytenumberandhemoglobinlevelinnormalanddiabeticwistarratmodel AT maharanilaillyzaapriasari acutetoxicitytestoftomanfishextractonerythrocytenumberandhemoglobinlevelinnormalanddiabeticwistarratmodel AT dewipuspitasari acutetoxicitytestoftomanfishextractonerythrocytenumberandhemoglobinlevelinnormalanddiabeticwistarratmodel |