Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box
Na<sup>+</sup>/H<sup>+</sup> exchange factor-1 (NHERF1), a multidomain PDZ scaffolding phosphoprotein, is required for the type II sodium-dependent phosphate cotransporter (NPT2A)-mediated renal phosphate absorption. Both PDZ1 and PDZ2 domains are involved in NPT2A-dependent...
Main Authors: | Tatyana Mamonova, Peter A. Friedman |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/3/1087 |
Similar Items
-
Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models
by: Xiaojun Wang, et al.
Published: (2022-04-01) -
Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
by: Luis H. Gutiérrez-González, et al.
Published: (2021-10-01) -
Bodas de plata: 25 años de la primera demostración del efecto directo del fósforo en la célula paratiroidea
by: Jordi Bover, et al.
Published: (2022-11-01) -
Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1
by: Barbara J. Clark, et al.
Published: (2016-06-01) -
An Unconventional Ligand for Scribble PDZ-4 Domain Mediates Its Interaction with Dusp26
by: Raffaella Gallo, et al.
Published: (2022-02-01)