Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs
Abstract Background Infection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effects of oral NSAID medication given in feed in acute...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Porcine Health Management |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40813-018-0081-x |
| _version_ | 1819026814242127872 |
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| author | Outi Hälli Minna Haimi-Hakala Tapio Laurila Claudio Oliviero Elina Viitasaari Toomas Orro Olli Peltoniemi Mika Scheinin Saija Sirén Anna Valros Mari Heinonen |
| author_facet | Outi Hälli Minna Haimi-Hakala Tapio Laurila Claudio Oliviero Elina Viitasaari Toomas Orro Olli Peltoniemi Mika Scheinin Saija Sirén Anna Valros Mari Heinonen |
| author_sort | Outi Hälli |
| collection | DOAJ |
| description | Abstract Background Infection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effects of oral NSAID medication given in feed in acute outbreaks of respiratory disease in finishing pigs. The short- and long-term impact of NSAID dosing on clinical signs, daily weight gain, blood parameters and behaviour of growing pigs in herds with acute respiratory infections were evaluated. Four finishing pig farms suffering from acute outbreaks of respiratory disease were visited thrice after outbreak onset (DAY 0, DAY 3 and DAY 30). Pigs with the most severe clinical signs (N = 160) were selected as representative pigs for the herd condition. These pigs were blood sampled, weighed, evaluated clinically and their behaviour was observed. After the first visit, half of the pens (five pigs per pen in four pens totalling 20 representative pigs per herd, altogether 80 pigs in four herds) were treated with oral ketoprofen (target dose 3 mg/kg) mixed in feed for three days and the other half (80 pigs) with a placebo. In three of the herds, some pigs were treated also with antimicrobials, and in one herd the only pharmaceutical treatment was ketoprofen or placebo. Results Compared to the placebo treatment, dosing of ketoprofen reduced sickness behaviour and lowered the rectal temperature of the pigs. Clinical signs, feed intake or blood parameters were not different between the treatment groups. Ketoprofen treatment was associated with somewhat reduced weight gain over the 30-day follow-up period. Concentration analysis of the S- and R-enantiomers of ketoprofen in serum samples collected on DAY 3 indicated successful oral drug administration. Conclusions Ketoprofen mainly influenced the behaviour of the pigs, while it had no effect on recovery from respiratory clinical signs. However, the medication may have been started after the most severe clinical phase of the respiratory disease was over, and this delay might complicate the evaluation of treatment effects. Possible negative impact of ketoprofen on production parameters requires further evaluation. |
| first_indexed | 2024-12-21T05:32:33Z |
| format | Article |
| id | doaj.art-4327d47f4626445dba4e1d1ca39e4254 |
| institution | Directory Open Access Journal |
| issn | 2055-5660 |
| language | English |
| last_indexed | 2024-12-21T05:32:33Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Porcine Health Management |
| spelling | doaj.art-4327d47f4626445dba4e1d1ca39e42542022-12-21T19:14:29ZengBMCPorcine Health Management2055-56602018-03-014111410.1186/s40813-018-0081-xEffect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigsOuti Hälli0Minna Haimi-Hakala1Tapio Laurila2Claudio Oliviero3Elina Viitasaari4Toomas Orro5Olli Peltoniemi6Mika Scheinin7Saija Sirén8Anna Valros9Mari Heinonen10Faculty of Veterinary Medicine, University of HelsinkiFaculty of Veterinary Medicine, University of HelsinkiFaculty of Veterinary Medicine, University of HelsinkiFaculty of Veterinary Medicine, University of HelsinkiFaculty of Veterinary Medicine, University of HelsinkiDepartment of Clinical Veterinary Medicine, Estonian University of Life SciencesFaculty of Veterinary Medicine, University of HelsinkiInstitute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University HospitalInstitute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University HospitalFaculty of Veterinary Medicine, University of HelsinkiFaculty of Veterinary Medicine, University of HelsinkiAbstract Background Infection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effects of oral NSAID medication given in feed in acute outbreaks of respiratory disease in finishing pigs. The short- and long-term impact of NSAID dosing on clinical signs, daily weight gain, blood parameters and behaviour of growing pigs in herds with acute respiratory infections were evaluated. Four finishing pig farms suffering from acute outbreaks of respiratory disease were visited thrice after outbreak onset (DAY 0, DAY 3 and DAY 30). Pigs with the most severe clinical signs (N = 160) were selected as representative pigs for the herd condition. These pigs were blood sampled, weighed, evaluated clinically and their behaviour was observed. After the first visit, half of the pens (five pigs per pen in four pens totalling 20 representative pigs per herd, altogether 80 pigs in four herds) were treated with oral ketoprofen (target dose 3 mg/kg) mixed in feed for three days and the other half (80 pigs) with a placebo. In three of the herds, some pigs were treated also with antimicrobials, and in one herd the only pharmaceutical treatment was ketoprofen or placebo. Results Compared to the placebo treatment, dosing of ketoprofen reduced sickness behaviour and lowered the rectal temperature of the pigs. Clinical signs, feed intake or blood parameters were not different between the treatment groups. Ketoprofen treatment was associated with somewhat reduced weight gain over the 30-day follow-up period. Concentration analysis of the S- and R-enantiomers of ketoprofen in serum samples collected on DAY 3 indicated successful oral drug administration. Conclusions Ketoprofen mainly influenced the behaviour of the pigs, while it had no effect on recovery from respiratory clinical signs. However, the medication may have been started after the most severe clinical phase of the respiratory disease was over, and this delay might complicate the evaluation of treatment effects. Possible negative impact of ketoprofen on production parameters requires further evaluation.http://link.springer.com/article/10.1186/s40813-018-0081-xBehaviourDaily weight gainAcute phase proteinsActinobacillus pleuropneumoniaeNSAIDPer os medication |
| spellingShingle | Outi Hälli Minna Haimi-Hakala Tapio Laurila Claudio Oliviero Elina Viitasaari Toomas Orro Olli Peltoniemi Mika Scheinin Saija Sirén Anna Valros Mari Heinonen Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs Porcine Health Management Behaviour Daily weight gain Acute phase proteins Actinobacillus pleuropneumoniae NSAID Per os medication |
| title | Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs |
| title_full | Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs |
| title_fullStr | Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs |
| title_full_unstemmed | Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs |
| title_short | Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs |
| title_sort | effect of oral ketoprofen treatment in acute respiratory disease outbreaks in finishing pigs |
| topic | Behaviour Daily weight gain Acute phase proteins Actinobacillus pleuropneumoniae NSAID Per os medication |
| url | http://link.springer.com/article/10.1186/s40813-018-0081-x |
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