TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1–mediated epithelial to mesenchymal transition in nasal epithelial cells

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1–mediated epithelial to mesenchymal transition in nasal epithelial cells

Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) is involved in the occurrence and development of CRSwNP. The T-cell immunoglobulin domain and the mucin domain 4 (TIM-4) is closely rela...

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Bibliographic Details
Main Authors: Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
TIM-4
macrophage
TGF-β1
EMT
CRSwNP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.941608/full

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