EXPERIENCE OF SEVERE SYSTEM TYPE OF JUVENILE RHEUMATOID ARTHRITIS TREATMENT WITH CYCLOSPORINE IN COMBINATION WITH DIFFERENT METHOTREXATE REGIMEN
<em>The article presents the case report of early debut and severe course of system type of juvenile rheumatoid arthritis, refractory to methotrexate and blockers of tumor necrotizing factor _ monotherapy. Successful treatment with cyclosporine in daily dose 4.4 mg/kg of body weight combined w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2009-01-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | http://vsp.spr-journal.ru:80/jour/article/view/1159 |
| Summary: | <em>The article presents the case report of early debut and severe course of system type of juvenile rheumatoid arthritis, refractory to methotrexate and blockers of tumor necrotizing factor _ monotherapy. Successful treatment with cyclosporine in daily dose 4.4 mg/kg of body weight combined with different regimen of methotrexate was described. Combined treatment with cyclosporine in daily dose 4.4 mg/kg of body weight and methotrexate in dose 15 mg/m2 of body surface once weekly intramuscularly and 50 mg/m2 of body surface once weekly intravenously during 8 weeks with further dose decrease to 25 mg/m2 of body surface intramuscularly induced remission development in 2–6 months, provided restoration of joints function, increased quality of life. Cyclosporine combined with pulse-therapy with methotrexate in more early stages stopped extra articulate signs of disease and reduced acute inflammatory joint’s lesions.</em><br /><strong><em>Key words: children, juvenile rheumatoid arthritis, cyclosporine, methotrexate.</em></strong><br /><span style="text-decoration: underline;"><em>(<em><em><em>Voprosy sovremennoi pediatrii — </em></em></em>Current Pediatrics. 2009;8(4):<em>142-150</em>)</em></span> |
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| ISSN: | 1682-5527 1682-5535 |