EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS
Objective: To assess the effects of Prunus dulcis on gastric epithelium affected by nonsteroidal anti-inflammatory drugs. Study Design: Laboratory based experimental study. Place and Duration of Study: Anatomy Department, Army Medical College Rawalpindi, in collaboration with National Institut...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Army Medical College Rawalpindi
2020-04-01
|
| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/4185/2603 |
| _version_ | 1818952245187706880 |
|---|---|
| author | Muhammad Saad Abdullah Shabnam Hamid Shadab Ahmed Butt |
| author_facet | Muhammad Saad Abdullah Shabnam Hamid Shadab Ahmed Butt |
| author_sort | Muhammad Saad Abdullah |
| collection | DOAJ |
| description | Objective: To assess the effects of Prunus dulcis on gastric epithelium affected by nonsteroidal anti-inflammatory drugs.
Study Design: Laboratory based experimental study.
Place and Duration of Study: Anatomy Department, Army Medical College Rawalpindi, in collaboration with National Institute of Health (NIH), Islamabad, from Jan 2015 to Dec 2015.
Methodology: Forty healthy adult male and female (BALB/c strain) mice, 9-11 weeks age, weighting 30-40gm were used in the experiment and were kept in standard conditions in animal house. Animals were divided into four equal groups. Group A served as control, whereas group B, C and D served as experimental groups. Animals in all groups were given standard lab diet for 60 days. In addition to standard lab diet, experimental groups C and D were given almond oil (extracted without peel of almonds) and finely ground almonds (with peel), respectively, via oral gavage once a day for 60 days. At 60th day, 400 mg/kg of ASA solution was given, via oral gavage needle, to induce gastric ulcers in animals of experimental groups B, C and D. Type of epithelium and height of epithelium were assessed under Light Microscope.
Results: Height and type of epithelium improved in experimental groups C and D on intergroup comparison. Whereas group D showed improved protection as compared to group C.
Conclusion: Prunus dulcis provides protection, to gastric epithelium, against gastric ulcers induced by non-steroidal anti inflammatory drugs. In addition, finely granular almonds provided better protective outcome in comparison with almond oil. |
| first_indexed | 2024-12-20T09:47:18Z |
| format | Article |
| id | doaj.art-432afadafc44456aa6bc139c63b3a6bb |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-20T09:47:18Z |
| publishDate | 2020-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-432afadafc44456aa6bc139c63b3a6bb2022-12-21T19:44:43ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-04-01702333337EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGSMuhammad Saad Abdullah0Shabnam Hamid1Shadab Ahmed Butt2Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To assess the effects of Prunus dulcis on gastric epithelium affected by nonsteroidal anti-inflammatory drugs. Study Design: Laboratory based experimental study. Place and Duration of Study: Anatomy Department, Army Medical College Rawalpindi, in collaboration with National Institute of Health (NIH), Islamabad, from Jan 2015 to Dec 2015. Methodology: Forty healthy adult male and female (BALB/c strain) mice, 9-11 weeks age, weighting 30-40gm were used in the experiment and were kept in standard conditions in animal house. Animals were divided into four equal groups. Group A served as control, whereas group B, C and D served as experimental groups. Animals in all groups were given standard lab diet for 60 days. In addition to standard lab diet, experimental groups C and D were given almond oil (extracted without peel of almonds) and finely ground almonds (with peel), respectively, via oral gavage once a day for 60 days. At 60th day, 400 mg/kg of ASA solution was given, via oral gavage needle, to induce gastric ulcers in animals of experimental groups B, C and D. Type of epithelium and height of epithelium were assessed under Light Microscope. Results: Height and type of epithelium improved in experimental groups C and D on intergroup comparison. Whereas group D showed improved protection as compared to group C. Conclusion: Prunus dulcis provides protection, to gastric epithelium, against gastric ulcers induced by non-steroidal anti inflammatory drugs. In addition, finely granular almonds provided better protective outcome in comparison with almond oil.https://www.pafmj.org/index.php/PAFMJ/article/view/4185/2603acetylsalicylic acidnonsteroidal anti-inflammatory drugs |
| spellingShingle | Muhammad Saad Abdullah Shabnam Hamid Shadab Ahmed Butt EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS Pakistan Armed Forces Medical Journal acetylsalicylic acid nonsteroidal anti-inflammatory drugs |
| title | EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS |
| title_full | EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS |
| title_fullStr | EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS |
| title_full_unstemmed | EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS |
| title_short | EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS |
| title_sort | effect of prunus dulcis on epithelial damage caused by nonsteroidal anti iflammatory drugs |
| topic | acetylsalicylic acid nonsteroidal anti-inflammatory drugs |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/4185/2603 |
| work_keys_str_mv | AT muhammadsaadabdullah effectofprunusdulcisonepithelialdamagecausedbynonsteroidalantiiflammatorydrugs AT shabnamhamid effectofprunusdulcisonepithelialdamagecausedbynonsteroidalantiiflammatorydrugs AT shadabahmedbutt effectofprunusdulcisonepithelialdamagecausedbynonsteroidalantiiflammatorydrugs |