Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia

Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia

Abstract Methotrexate (MTX) is the most widely used disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis (RA). Many studies have attempted to understand the genetic risk factors that affect the therapeutic outcomes in RA patients treated with MTX. Unlike other studies that focus on...

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Bibliographic Details
Main Authors: Hong Xi Sha, Kumar Veerapen, Sook Khuan Chow, Suk Chyn Gun, Ing Soo Lau, Renee Lay Hong Lim, Zaliha Zulkifli, Yoon-Yen Yow, Suat Cheng Peh, Jung Shan Hwang
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15991-0

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