Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples

The association of specific immune cell types with SARS-CoV-2 severity is not fully understood. Here the authors analyse PBMC from individuals recovered from COVID-19 and propose immune cell signatures post recovery that are associated with disease severity.

Bibliographic Details
Main Authors: Thomas Liechti, Yaser Iftikhar, Massimo Mangino, Margaret Beddall, Charles W. Goss, Jane A. O’Halloran, Philip A. Mudd, Mario Roederer
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34638-2
_version_ 1811210956006490112
author Thomas Liechti
Yaser Iftikhar
Massimo Mangino
Margaret Beddall
Charles W. Goss
Jane A. O’Halloran
Philip A. Mudd
Mario Roederer
author_facet Thomas Liechti
Yaser Iftikhar
Massimo Mangino
Margaret Beddall
Charles W. Goss
Jane A. O’Halloran
Philip A. Mudd
Mario Roederer
author_sort Thomas Liechti
collection DOAJ
description The association of specific immune cell types with SARS-CoV-2 severity is not fully understood. Here the authors analyse PBMC from individuals recovered from COVID-19 and propose immune cell signatures post recovery that are associated with disease severity.
first_indexed 2024-04-12T05:04:49Z
format Article
id doaj.art-4332ecc498cb426a98bc215965288a51
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-04-12T05:04:49Z
publishDate 2022-11-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-4332ecc498cb426a98bc215965288a512022-12-22T03:46:54ZengNature PortfolioNature Communications2041-17232022-11-0113111710.1038/s41467-022-34638-2Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samplesThomas Liechti0Yaser Iftikhar1Massimo Mangino2Margaret Beddall3Charles W. Goss4Jane A. O’Halloran5Philip A. Mudd6Mario Roederer7ImmunoTechnology Section, Vaccine Research Center, NIAID, NIHImmunoTechnology Section, Vaccine Research Center, NIAID, NIHDepartment of Twin Research & Genetic Epidemiology, King’s College of LondonImmunoTechnology Section, Vaccine Research Center, NIAID, NIHDivision of Biostatistics, Washington University School of MedicineDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of MedicineDepartment of Emergency Medicine, Washington University School of MedicineImmunoTechnology Section, Vaccine Research Center, NIAID, NIHThe association of specific immune cell types with SARS-CoV-2 severity is not fully understood. Here the authors analyse PBMC from individuals recovered from COVID-19 and propose immune cell signatures post recovery that are associated with disease severity.https://doi.org/10.1038/s41467-022-34638-2
spellingShingle Thomas Liechti
Yaser Iftikhar
Massimo Mangino
Margaret Beddall
Charles W. Goss
Jane A. O’Halloran
Philip A. Mudd
Mario Roederer
Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
Nature Communications
title Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
title_full Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
title_fullStr Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
title_full_unstemmed Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
title_short Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
title_sort immune phenotypes that are associated with subsequent covid 19 severity inferred from post recovery samples
url https://doi.org/10.1038/s41467-022-34638-2
work_keys_str_mv AT thomasliechti immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT yaseriftikhar immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT massimomangino immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT margaretbeddall immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT charleswgoss immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT janeaohalloran immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT philipamudd immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples
AT marioroederer immunephenotypesthatareassociatedwithsubsequentcovid19severityinferredfrompostrecoverysamples