Should Cystatin C eGFR Become Routine Clinical Practice?
Kidney function assessment is crucial for diagnosing and managing kidney diseases. Glomerular filtration rate (GFR) is widely used as an indicator of kidney function, but its direct measurement is challenging. Serum creatinine, a commonly used marker for estimating GFR (eGFR), has limitations in acc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/7/1075 |
| _version_ | 1827733668739678208 |
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| author | Sebastian Spencer Robert Desborough Sunil Bhandari |
| author_facet | Sebastian Spencer Robert Desborough Sunil Bhandari |
| author_sort | Sebastian Spencer |
| collection | DOAJ |
| description | Kidney function assessment is crucial for diagnosing and managing kidney diseases. Glomerular filtration rate (GFR) is widely used as an indicator of kidney function, but its direct measurement is challenging. Serum creatinine, a commonly used marker for estimating GFR (eGFR), has limitations in accuracy and sensitivity. Cystatin C, a protein freely filtered by the glomerulus, has emerged as a promising alternative marker for kidney function. It is unaffected by muscle mass and shows stronger associations with cardiovascular disease and mortality than creatinine. Various equations have been developed to estimate GFR using creatinine or cystatin C alone or in combination. The CKD-EPI<sub>creat-cys</sub> equation combining both markers demonstrates improved accuracy in GFR estimation, especially for individuals with eGFR values of 45–59 mL/min/1.73 m<sup>2</sup>. Cystatin C-based estimates of GFR outperform creatinine-based estimates in predicting clinical outcomes and identifying patients at higher risk, particularly in elderly and non-white ethnic groups. Cystatin C offers advantages over creatinine as a marker of kidney function. It is not influenced by non-kidney factors and provides more accurate estimation of GFR, aiding in the early detection of kidney disease and predicting adverse outcomes. Incorporating cystatin C into routine kidney function assessment may improve patient risk stratification and guide clinical decision-making. However, widespread adoption of cystatin C testing requires increased availability and accessibility in clinical laboratories. Further research and implementation efforts are needed to fully realize the potential of cystatin C in kidney function assessment and improving patient outcomes. |
| first_indexed | 2024-03-11T01:15:25Z |
| format | Article |
| id | doaj.art-43351b87f5674995af0ce5bb4fe70814 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T01:15:25Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-43351b87f5674995af0ce5bb4fe708142023-11-18T18:31:04ZengMDPI AGBiomolecules2218-273X2023-07-01137107510.3390/biom13071075Should Cystatin C eGFR Become Routine Clinical Practice?Sebastian Spencer0Robert Desborough1Sunil Bhandari2School of Medical Sciences, University of Hull, Hull HU6 7RX, UKHull York Medical School, University of Hull, Hull HU6 7RU, UKHull York Medical School, University of Hull, Hull HU6 7RU, UKKidney function assessment is crucial for diagnosing and managing kidney diseases. Glomerular filtration rate (GFR) is widely used as an indicator of kidney function, but its direct measurement is challenging. Serum creatinine, a commonly used marker for estimating GFR (eGFR), has limitations in accuracy and sensitivity. Cystatin C, a protein freely filtered by the glomerulus, has emerged as a promising alternative marker for kidney function. It is unaffected by muscle mass and shows stronger associations with cardiovascular disease and mortality than creatinine. Various equations have been developed to estimate GFR using creatinine or cystatin C alone or in combination. The CKD-EPI<sub>creat-cys</sub> equation combining both markers demonstrates improved accuracy in GFR estimation, especially for individuals with eGFR values of 45–59 mL/min/1.73 m<sup>2</sup>. Cystatin C-based estimates of GFR outperform creatinine-based estimates in predicting clinical outcomes and identifying patients at higher risk, particularly in elderly and non-white ethnic groups. Cystatin C offers advantages over creatinine as a marker of kidney function. It is not influenced by non-kidney factors and provides more accurate estimation of GFR, aiding in the early detection of kidney disease and predicting adverse outcomes. Incorporating cystatin C into routine kidney function assessment may improve patient risk stratification and guide clinical decision-making. However, widespread adoption of cystatin C testing requires increased availability and accessibility in clinical laboratories. Further research and implementation efforts are needed to fully realize the potential of cystatin C in kidney function assessment and improving patient outcomes.https://www.mdpi.com/2218-273X/13/7/1075chronic kidney diseasecardiovascular diseasecystatin CGFR |
| spellingShingle | Sebastian Spencer Robert Desborough Sunil Bhandari Should Cystatin C eGFR Become Routine Clinical Practice? Biomolecules chronic kidney disease cardiovascular disease cystatin C GFR |
| title | Should Cystatin C eGFR Become Routine Clinical Practice? |
| title_full | Should Cystatin C eGFR Become Routine Clinical Practice? |
| title_fullStr | Should Cystatin C eGFR Become Routine Clinical Practice? |
| title_full_unstemmed | Should Cystatin C eGFR Become Routine Clinical Practice? |
| title_short | Should Cystatin C eGFR Become Routine Clinical Practice? |
| title_sort | should cystatin c egfr become routine clinical practice |
| topic | chronic kidney disease cardiovascular disease cystatin C GFR |
| url | https://www.mdpi.com/2218-273X/13/7/1075 |
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