Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546314000138 |
| _version_ | 1818490690165800960 |
|---|---|
| author | Sávio T. Farias Thais G. Rêgo Marco V. José |
| author_facet | Sávio T. Farias Thais G. Rêgo Marco V. José |
| author_sort | Sávio T. Farias |
| collection | DOAJ |
| description | We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA. |
| first_indexed | 2024-12-10T17:20:21Z |
| format | Article |
| id | doaj.art-4335e2045baa417aa43a4afbde272022 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-10T17:20:21Z |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-4335e2045baa417aa43a4afbde2720222022-12-22T01:40:00ZengWileyFEBS Open Bio2211-54632014-01-014C17517810.1016/j.fob.2014.01.010Origin and evolution of the Peptidyl Transferase Center from proto-tRNAsSávio T. Farias0Thais G. Rêgo1Marco V. José2Universidade Federal da Paraîba, Campus I, Departamento de Biologia Molecular, Laboratório de Genética Evolutiva Paulo Leminsk, João Pessoa, Paraíba, BrazilUniversidade Federal da Paraíba, Campus I, Departamento de Informática, João Pessoa, Paraíba, BrazilTheoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, CP 04510, DF, MexicoWe tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA.http://www.sciencedirect.com/science/article/pii/S2211546314000138RibosomePeptidyl Transferase CenterOrigintRNA |
| spellingShingle | Sávio T. Farias Thais G. Rêgo Marco V. José Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs FEBS Open Bio Ribosome Peptidyl Transferase Center Origin tRNA |
| title | Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs |
| title_full | Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs |
| title_fullStr | Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs |
| title_full_unstemmed | Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs |
| title_short | Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs |
| title_sort | origin and evolution of the peptidyl transferase center from proto trnas |
| topic | Ribosome Peptidyl Transferase Center Origin tRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2211546314000138 |
| work_keys_str_mv | AT saviotfarias originandevolutionofthepeptidyltransferasecenterfromprototrnas AT thaisgrego originandevolutionofthepeptidyltransferasecenterfromprototrnas AT marcovjose originandevolutionofthepeptidyltransferasecenterfromprototrnas |