Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review
Recent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037018300977 |
| _version_ | 1818153568613433344 |
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| author | Vladimir A. Kornev Ekaterina A. Grebenik Anna B. Solovieva Ruslan I. Dmitriev Peter S. Timashev |
| author_facet | Vladimir A. Kornev Ekaterina A. Grebenik Anna B. Solovieva Ruslan I. Dmitriev Peter S. Timashev |
| author_sort | Vladimir A. Kornev |
| collection | DOAJ |
| description | Recent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and functional restoration of damaged tissues by providing mechanical support and navigating cell fate. Hydrogels also show the potential for brain injury therapy due to their broadly tunable physical, chemical, and biological properties. Hydrogel polymers, which have been extensively implemented in recent brain injury repair studies, include hyaluronic acid, collagen type I, alginate, chitosan, methylcellulose, Matrigel, fibrin, gellan gum, self-assembling peptides and proteins, poly(ethylene glycol), methacrylates, and methacrylamides. When viewed as tools for neuroregeneration, hydrogels can be divided into: (1) hydrogels suitable for brain injury therapy, (2) hydrogels that do not meet basic therapeutic requirements and (3) promising hydrogels which meet the criteria for further investigations. Our analysis shows that fibrin, collagen I and self-assembling peptide-based hydrogels display very attractive properties for neuroregeneration. Keywords: biomaterials, brain injury, hydrogel, nerve tissue engineering, neural stem cells, stroke |
| first_indexed | 2024-12-11T14:12:41Z |
| format | Article |
| id | doaj.art-43387f4e870546f796d8f56087cee196 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-11T14:12:41Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-43387f4e870546f796d8f56087cee1962022-12-22T01:03:22ZengElsevierComputational and Structural Biotechnology Journal2001-03702018-01-0116488502Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art reviewVladimir A. Kornev0Ekaterina A. Grebenik1Anna B. Solovieva2Ruslan I. Dmitriev3Peter S. Timashev4Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., Moscow 119991, Russian FederationInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., Moscow 119991, Russian FederationN. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina st., Moscow 117977, Russian FederationInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., Moscow 119991, Russian Federation; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland; Corresponding author at: Cavanagh Pharmacy Building, University College Cork, College Road, Cork, Ireland.Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., Moscow 119991, Russian Federation; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina st., Moscow 117977, Russian Federation; Institute of Photonic Technologies, Research Center “Crystallography and Photonics” Russian Academy of Sciences, 2 Pionerskaya st., Troitsk, Moscow 108840, Russian FederationRecent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and functional restoration of damaged tissues by providing mechanical support and navigating cell fate. Hydrogels also show the potential for brain injury therapy due to their broadly tunable physical, chemical, and biological properties. Hydrogel polymers, which have been extensively implemented in recent brain injury repair studies, include hyaluronic acid, collagen type I, alginate, chitosan, methylcellulose, Matrigel, fibrin, gellan gum, self-assembling peptides and proteins, poly(ethylene glycol), methacrylates, and methacrylamides. When viewed as tools for neuroregeneration, hydrogels can be divided into: (1) hydrogels suitable for brain injury therapy, (2) hydrogels that do not meet basic therapeutic requirements and (3) promising hydrogels which meet the criteria for further investigations. Our analysis shows that fibrin, collagen I and self-assembling peptide-based hydrogels display very attractive properties for neuroregeneration. Keywords: biomaterials, brain injury, hydrogel, nerve tissue engineering, neural stem cells, strokehttp://www.sciencedirect.com/science/article/pii/S2001037018300977 |
| spellingShingle | Vladimir A. Kornev Ekaterina A. Grebenik Anna B. Solovieva Ruslan I. Dmitriev Peter S. Timashev Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review Computational and Structural Biotechnology Journal |
| title | Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review |
| title_full | Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review |
| title_fullStr | Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review |
| title_full_unstemmed | Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review |
| title_short | Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review |
| title_sort | hydrogel assisted neuroregeneration approaches towards brain injury therapy a state of the art review |
| url | http://www.sciencedirect.com/science/article/pii/S2001037018300977 |
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