Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-relate...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13994 |
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| author | Natalia Jermakow Weronika Skarżyńska Katarzyna Lewandowska Ewelina Kiernozek Katarzyna Goździk Anna Mietelska-Porowska Nadzieja Drela Urszula Wojda Maria Doligalska |
| author_facet | Natalia Jermakow Weronika Skarżyńska Katarzyna Lewandowska Ewelina Kiernozek Katarzyna Goździk Anna Mietelska-Porowska Nadzieja Drela Urszula Wojda Maria Doligalska |
| author_sort | Natalia Jermakow |
| collection | DOAJ |
| description | Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-related neuroinflammation, especially macrophages in the nervous tissue. Here, intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged <i>Heligmosomoides polygyrus</i> infection in C57BL/6 mice. The changes in the brain coincided with the increase in M1 macrophages, reduced survivin level, enhanced APP and GFAP expression, chitin-like chains deposition in the brain and deterioration behaviour manifestations. These changes were also observed in transgenic C57BL/6 mice predisposed to develop neurodegeneration typical for Alzheimer’s disease in response to pathogenic stimuli. Interestingly, in mice infected with the nematode only, the greater M2 macrophage population resulted in better results in the forced swim test. Given the growing burden of neurodegenerative diseases, understanding such interactive associations can have significant implications for ageing health strategies and disease monitoring. |
| first_indexed | 2024-03-10T22:40:10Z |
| format | Article |
| id | doaj.art-4338f54f8dc843a6b30c556844cf120a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:10Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4338f54f8dc843a6b30c556844cf120a2023-11-19T11:06:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181399410.3390/ijms241813994Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing MiceNatalia Jermakow0Weronika Skarżyńska1Katarzyna Lewandowska2Ewelina Kiernozek3Katarzyna Goździk4Anna Mietelska-Porowska5Nadzieja Drela6Urszula Wojda7Maria Doligalska8Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandFaculty of Chemistry, Nicolaus Copernicus in Toruń, Gagarina 7, 87-100 Toruń, PolandFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Ludwika Pasteura 3, 02-093 Warszawa, PolandFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Ludwika Pasteura 3, 02-093 Warszawa, PolandFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, PolandParasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-related neuroinflammation, especially macrophages in the nervous tissue. Here, intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged <i>Heligmosomoides polygyrus</i> infection in C57BL/6 mice. The changes in the brain coincided with the increase in M1 macrophages, reduced survivin level, enhanced APP and GFAP expression, chitin-like chains deposition in the brain and deterioration behaviour manifestations. These changes were also observed in transgenic C57BL/6 mice predisposed to develop neurodegeneration typical for Alzheimer’s disease in response to pathogenic stimuli. Interestingly, in mice infected with the nematode only, the greater M2 macrophage population resulted in better results in the forced swim test. Given the growing burden of neurodegenerative diseases, understanding such interactive associations can have significant implications for ageing health strategies and disease monitoring.https://www.mdpi.com/1422-0067/24/18/13994helminthspersistent infectionneuroinflammationageingneurodegenerative diseasesimmunomodulation |
| spellingShingle | Natalia Jermakow Weronika Skarżyńska Katarzyna Lewandowska Ewelina Kiernozek Katarzyna Goździk Anna Mietelska-Porowska Nadzieja Drela Urszula Wojda Maria Doligalska Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice International Journal of Molecular Sciences helminths persistent infection neuroinflammation ageing neurodegenerative diseases immunomodulation |
| title | Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice |
| title_full | Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice |
| title_fullStr | Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice |
| title_full_unstemmed | Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice |
| title_short | Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice |
| title_sort | modulation of lps induced neurodegeneration by intestinal helminth infection in ageing mice |
| topic | helminths persistent infection neuroinflammation ageing neurodegenerative diseases immunomodulation |
| url | https://www.mdpi.com/1422-0067/24/18/13994 |
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