The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress
Background: Lead is a highly toxic metal of great public health importance. Objectives: This cross-sectional study was conducted to evaluate the kidney and liver function status and the markers of oxidative stress among lead recycling factory workers in Anambra State, Nigeria. Methods: A total of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hamadan University of Medical Sciences
2023-06-01
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| Series: | Avicenna Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://ajmb.umsha.ac.ir/PDF/ajmb-11-41.pdf |
| _version_ | 1797742960128819200 |
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| author | Christian Ejike Onah Chinwemma Florence Onah Stephen Monday Suru Chinedu Michael Olisah Alfred Friday Ehiaghe Chukwuemeka Emmanuel Ogbodo Wuraola Serah Nnaemeka Ukamaka Ann Ijeomah Chukwuemeka Samuel Meludu Chudi Emmanuel Dioka |
| author_facet | Christian Ejike Onah Chinwemma Florence Onah Stephen Monday Suru Chinedu Michael Olisah Alfred Friday Ehiaghe Chukwuemeka Emmanuel Ogbodo Wuraola Serah Nnaemeka Ukamaka Ann Ijeomah Chukwuemeka Samuel Meludu Chudi Emmanuel Dioka |
| author_sort | Christian Ejike Onah |
| collection | DOAJ |
| description | Background: Lead is a highly toxic metal of great public health importance.
Objectives: This cross-sectional study was conducted to evaluate the kidney and liver function status and the markers of oxidative stress among lead recycling factory workers in Anambra State, Nigeria.
Methods: A total of 82 subjects (41 experimental and 41 control subjects) aged 20-60 years were recruited in this study. Lead levels in whole blood were measured using atomic absorption spectrometry. Serum malondialdehyde (MDA) and uric acid levels as well as the activities of glutathione S-transferase (GST), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) were measured using the spectrophotometric method. Superoxide dismutase (SOD) and catalase activities were determined using colorimetric method and Berthelot’s and Jaffe slot methods were used to measure urea and creatinine levels, respectively.
Results: The mean activities of SOD, GST, and catalase as well as estimated glomerular filtration rate (eGFR) were significantly lower in lead recycling workers compared with control group (P<0.05), whereas the mean activities of ALT, AST, ALP, and γ-GT, as well as blood lead, MDA, urea, creatinine, and uric acid levels significantly increased in lead recycling workers (P<0.05). Furthermore, blood lead level was found positively correlated with MDA and creatinine levels but negatively with eGFR and GST levels (P<0.05). MDA level showed positive and negative correlations with creatinine and eGFR (P<0.05), respectively.
Conclusion: This study revealed significant alterations in the levels of some biochemical and oxidative stress parameters in liver and kidney in lead recycling factory workers and showed a possible link between oxidative stress and the toxic effects of lead on the kidney and liver. |
| first_indexed | 2024-03-12T14:48:40Z |
| format | Article |
| id | doaj.art-433a2a84b9094f638f1a62f2f710f167 |
| institution | Directory Open Access Journal |
| issn | 2345-4113 |
| language | English |
| last_indexed | 2024-03-12T14:48:40Z |
| publishDate | 2023-06-01 |
| publisher | Hamadan University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Medical Biochemistry |
| spelling | doaj.art-433a2a84b9094f638f1a62f2f710f1672023-08-15T20:52:24ZengHamadan University of Medical SciencesAvicenna Journal of Medical Biochemistry2345-41132023-06-01111414510.34172/ajmb.2023.2430The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative StressChristian Ejike Onah 0https://orcid.org/0000-0002-4611-392XChinwemma Florence Onah1Stephen Monday Suru 2Chinedu Michael Olisah3Alfred Friday Ehiaghe4Chukwuemeka Emmanuel Ogbodo5https://orcid.org/0000-0002-2560-6995Wuraola Serah Nnaemeka 6Ukamaka Ann Ijeomah7Chukwuemeka Samuel Meludu8Chudi Emmanuel Dioka9Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Nursing Services, Nnamdi Azikiwe University Teaching Hospital, Nnewi, NigeriaDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odimegwu Ojukwu University, Uli, NigeriaDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Biochemistry, Faculty of Natural and Applied Sciences, Nasarawa State University Keffi, NigeriaDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria Background: Lead is a highly toxic metal of great public health importance. Objectives: This cross-sectional study was conducted to evaluate the kidney and liver function status and the markers of oxidative stress among lead recycling factory workers in Anambra State, Nigeria. Methods: A total of 82 subjects (41 experimental and 41 control subjects) aged 20-60 years were recruited in this study. Lead levels in whole blood were measured using atomic absorption spectrometry. Serum malondialdehyde (MDA) and uric acid levels as well as the activities of glutathione S-transferase (GST), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) were measured using the spectrophotometric method. Superoxide dismutase (SOD) and catalase activities were determined using colorimetric method and Berthelot’s and Jaffe slot methods were used to measure urea and creatinine levels, respectively. Results: The mean activities of SOD, GST, and catalase as well as estimated glomerular filtration rate (eGFR) were significantly lower in lead recycling workers compared with control group (P<0.05), whereas the mean activities of ALT, AST, ALP, and γ-GT, as well as blood lead, MDA, urea, creatinine, and uric acid levels significantly increased in lead recycling workers (P<0.05). Furthermore, blood lead level was found positively correlated with MDA and creatinine levels but negatively with eGFR and GST levels (P<0.05). MDA level showed positive and negative correlations with creatinine and eGFR (P<0.05), respectively. Conclusion: This study revealed significant alterations in the levels of some biochemical and oxidative stress parameters in liver and kidney in lead recycling factory workers and showed a possible link between oxidative stress and the toxic effects of lead on the kidney and liver.https://ajmb.umsha.ac.ir/PDF/ajmb-11-41.pdfleadantioxidantsoxidative stresskidneyliverenzymes |
| spellingShingle | Christian Ejike Onah Chinwemma Florence Onah Stephen Monday Suru Chinedu Michael Olisah Alfred Friday Ehiaghe Chukwuemeka Emmanuel Ogbodo Wuraola Serah Nnaemeka Ukamaka Ann Ijeomah Chukwuemeka Samuel Meludu Chudi Emmanuel Dioka The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress Avicenna Journal of Medical Biochemistry lead antioxidants oxidative stress kidney liver enzymes |
| title | The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress |
| title_full | The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress |
| title_fullStr | The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress |
| title_full_unstemmed | The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress |
| title_short | The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress |
| title_sort | effects of lead on some markers of liver and kidney functions of lead recycling factory workers are mediated through increased oxidative stress |
| topic | lead antioxidants oxidative stress kidney liver enzymes |
| url | https://ajmb.umsha.ac.ir/PDF/ajmb-11-41.pdf |
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