Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers
Ovarian cancer (OvCa) is a destructive malignancy due to difficulties in early detection and late advanced-stage diagnoses, leading to high morbidity and mortality rates for women. Currently, the quality treatment for OvCa includes tumor debulking surgery and intravenous platinum-based chemotherapy....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5480 |
| _version_ | 1797512701545545728 |
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| author | Melayshia McFadden Santosh Kumar Singh Gabriela Oprea-Ilies Rajesh Singh |
| author_facet | Melayshia McFadden Santosh Kumar Singh Gabriela Oprea-Ilies Rajesh Singh |
| author_sort | Melayshia McFadden |
| collection | DOAJ |
| description | Ovarian cancer (OvCa) is a destructive malignancy due to difficulties in early detection and late advanced-stage diagnoses, leading to high morbidity and mortality rates for women. Currently, the quality treatment for OvCa includes tumor debulking surgery and intravenous platinum-based chemotherapy. However, numerous patients either succumb to the disease or undergo relapse due to drug resistance, such as to platinum drugs. There are several mechanisms that cause cancer cells’ resistance to chemotherapy, such as inactivation of the drug, alteration of the drug targets, enhancement of DNA repair of drug-induced damage, and multidrug resistance (MDR). Some targeted therapies, such as nanoparticles, and some non-targeted therapies, such as natural products, reverse MDR. Nanoparticle targeting can lead to the reversal of MDR by allowing direct access for agents to specific tumor sites. Natural products have many anti-cancer properties that adversely regulate the factors contributing to MDR. The present review displays the current problems in OvCa treatments that lead to resistance and proposes using nanotechnology and natural products to overcome drug resistance. |
| first_indexed | 2024-03-10T06:05:25Z |
| format | Article |
| id | doaj.art-433a7f45acae4b5a9b21636581610603 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:05:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-433a7f45acae4b5a9b216365816106032023-11-22T20:35:52ZengMDPI AGCancers2072-66942021-10-011321548010.3390/cancers13215480Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian CancersMelayshia McFadden0Santosh Kumar Singh1Gabriela Oprea-Ilies2Rajesh Singh3Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USADepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USADepartment of Pathology & Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USAOvarian cancer (OvCa) is a destructive malignancy due to difficulties in early detection and late advanced-stage diagnoses, leading to high morbidity and mortality rates for women. Currently, the quality treatment for OvCa includes tumor debulking surgery and intravenous platinum-based chemotherapy. However, numerous patients either succumb to the disease or undergo relapse due to drug resistance, such as to platinum drugs. There are several mechanisms that cause cancer cells’ resistance to chemotherapy, such as inactivation of the drug, alteration of the drug targets, enhancement of DNA repair of drug-induced damage, and multidrug resistance (MDR). Some targeted therapies, such as nanoparticles, and some non-targeted therapies, such as natural products, reverse MDR. Nanoparticle targeting can lead to the reversal of MDR by allowing direct access for agents to specific tumor sites. Natural products have many anti-cancer properties that adversely regulate the factors contributing to MDR. The present review displays the current problems in OvCa treatments that lead to resistance and proposes using nanotechnology and natural products to overcome drug resistance.https://www.mdpi.com/2072-6694/13/21/5480ovarian cancernanoparticlestargeted drug deliverydrug resistance |
| spellingShingle | Melayshia McFadden Santosh Kumar Singh Gabriela Oprea-Ilies Rajesh Singh Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers Cancers ovarian cancer nanoparticles targeted drug delivery drug resistance |
| title | Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers |
| title_full | Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers |
| title_fullStr | Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers |
| title_full_unstemmed | Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers |
| title_short | Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers |
| title_sort | nano based drug delivery and targeting to overcome drug resistance of ovarian cancers |
| topic | ovarian cancer nanoparticles targeted drug delivery drug resistance |
| url | https://www.mdpi.com/2072-6694/13/21/5480 |
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