Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci

Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci

ABSTRACT Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. A...

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Bibliographic Details
Main Authors: Sruti DebRoy, William C. Shropshire, Luis Vega, Chau Tran, Nicola Horstmann, Piyali Mukherjee, Selvalakshmi Selvaraj-Anand, Truc T. Tran, Jordan Bremer, Marc Gohel, Cesar A. Arias, Anthony R. Flores, Samuel A. Shelburne
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mSystems
Subjects:
Streptococcus
CovRS
acapsular
Online Access:https://journals.asm.org/doi/10.1128/msystems.00227-23

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