Comparison of Reproductive Function Between Normal and Hyperandrogenemia Conditions in Female Mice With Deletion of Hepatic Androgen Receptor

Comparison of Reproductive Function Between Normal and Hyperandrogenemia Conditions in Female Mice With Deletion of Hepatic Androgen Receptor

Obesity, altered glucose homeostasis, hyperinsulinism, and reproductive dysfunction develops in female humans and mammals with hyperandrogenism. We previously reported that low dose dihydrotestosterone (DHT) administration results in metabolic and reproductive dysfunction in the absence of obesity i...

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Bibliographic Details
Main Authors: Mingxiao Feng, Sara Divall, Dustin Jones, Vaibhave Ubba, Xiaomin Fu, Ling Yang, Hong Wang, Xiaofeng Yang, Sheng Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
PCOS: polycystic ovary syndrome
DHT
dihydrotestosterone
androgen receptor (AR)
liver
puberty
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.868572/full

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