GluN2A subunit-containing NMDA receptors are the preferential neuronal targets of homocysteine

GluN2A subunit-containing NMDA receptors are the preferential neuronal targets of homocysteine

Homocysteine (HCY) is an endogenous redox active amino acid, best known as contributor to various neurodegenerative disorders. Although it is known that HCY can activate NMDA receptors (NMDARs), the mechanisms of its action on receptors composed of different NMDA receptor subunits remains almost unk...

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Bibliographic Details
Main Authors: Dmitry A Sibarov, Polina A Abushik, Rashid Giniatullin, Sergei M Antonov
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Homocysteine
Neurons
Glutamate
Desensitization
NMDA receptor
primary culture
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00246/full

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