Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression

Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression

Abstract Plant-derived nanovesicles (PDNVs) have been proposed as a major mechanism for the inter-kingdom interaction and communication, but the effector components enclosed in the vesicles and the mechanisms involved are largely unknown. The plant Artemisia annua is known as an anti-malaria agent t...

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Bibliographic Details
Main Authors: Jinfeng Liu, Jiaxin Xiang, Cuiyuan Jin, Lusha Ye, Lei Wang, Yanan Gao, Nianyin Lv, Junfeng Zhang, Fuping You, Hongzhi Qiao, Liyun Shi
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Artemisia-derived nanovesicles
Tumor-associated macrophages
mtDNA
cGAS-STING
Online Access:https://doi.org/10.1186/s12951-023-01835-0

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