Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions
Mitochondria plays an essential role in regulating cellular metabolic homeostasis, proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many age-related pathologies. Evidence supports that the dysfunction of mitochondria and the decline of mitochondrial DNA copy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1361289/full |
| _version_ | 1797202879260393472 |
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| author | Wenhan Ju Yuewen Zhao Yi Yu Shuai Zhao Shan Xiang Fang Lian |
| author_facet | Wenhan Ju Yuewen Zhao Yi Yu Shuai Zhao Shan Xiang Fang Lian |
| author_sort | Wenhan Ju |
| collection | DOAJ |
| description | Mitochondria plays an essential role in regulating cellular metabolic homeostasis, proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many age-related pathologies. Evidence supports that the dysfunction of mitochondria and the decline of mitochondrial DNA copy number negatively affect ovarian aging. However, the mechanism of ovarian aging is still unclear. Treatment methods, including antioxidant applications, mitochondrial transplantation, emerging biomaterials, and advanced technologies, are being used to improve mitochondrial function and restore oocyte quality. This article reviews key evidence and research updates on mitochondrial damage in the pathogenesis of ovarian aging, emphasizing that mitochondrial damage may accelerate and lead to cellular senescence and ovarian aging, as well as exploring potential methods for using mitochondrial mechanisms to slow down aging and improve oocyte quality. |
| first_indexed | 2024-04-24T08:10:27Z |
| format | Article |
| id | doaj.art-4343aef8e04b4814b3e1e0fe5ce74507 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T08:10:27Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4343aef8e04b4814b3e1e0fe5ce745072024-04-17T04:56:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13612891361289Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventionsWenhan Ju0Yuewen Zhao1Yi Yu2Shuai Zhao3Shan Xiang4Fang Lian5The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCReATe Fertility Centre, Toronto, ON, CanadaDepartment of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaMitochondria plays an essential role in regulating cellular metabolic homeostasis, proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many age-related pathologies. Evidence supports that the dysfunction of mitochondria and the decline of mitochondrial DNA copy number negatively affect ovarian aging. However, the mechanism of ovarian aging is still unclear. Treatment methods, including antioxidant applications, mitochondrial transplantation, emerging biomaterials, and advanced technologies, are being used to improve mitochondrial function and restore oocyte quality. This article reviews key evidence and research updates on mitochondrial damage in the pathogenesis of ovarian aging, emphasizing that mitochondrial damage may accelerate and lead to cellular senescence and ovarian aging, as well as exploring potential methods for using mitochondrial mechanisms to slow down aging and improve oocyte quality.https://www.frontiersin.org/articles/10.3389/fendo.2024.1361289/fulloocyteagingmitochondriafertility preservationmechanism |
| spellingShingle | Wenhan Ju Yuewen Zhao Yi Yu Shuai Zhao Shan Xiang Fang Lian Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions Frontiers in Endocrinology oocyte aging mitochondria fertility preservation mechanism |
| title | Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| title_full | Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| title_fullStr | Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| title_full_unstemmed | Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| title_short | Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| title_sort | mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions |
| topic | oocyte aging mitochondria fertility preservation mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1361289/full |
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