<i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses
RNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in dif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/8/751 |
| _version_ | 1818570620813705216 |
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| author | Laura R. Newburn K. Andrew White |
| author_facet | Laura R. Newburn K. Andrew White |
| author_sort | Laura R. Newburn |
| collection | DOAJ |
| description | RNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in different forms, including double-stranded RNA, coding-sense single-stranded RNA, and noncoding single-stranded RNA. Genera that possess these genome types include, respectively, <i>Orbivirus</i> (e.g., Bluetongue virus), <i>Dianthovirus</i> (e.g., Red clover necrotic mosaic virus) and <i>Alphainfluenzavirus</i> (e.g., Influenza A virus). Despite their distinct genomic features and diverse host ranges (i.e., animals, plants, and humans, respectively) each of these viruses uses <i>trans</i>-acting RNA−RNA interactions (tRRIs) to facilitate co-packaging of their segmented genome. The tRRIs occur between different viral genome segments and direct the selective packaging of a complete genome complement. Here we explore the current state of understanding of tRRI-mediated co-packaging in the abovementioned viruses and examine other known and potential functions for this class of RNA−RNA interaction. |
| first_indexed | 2024-12-14T13:44:21Z |
| format | Article |
| id | doaj.art-43485958d237429385fc22cbaaa86c7f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-14T13:44:21Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-43485958d237429385fc22cbaaa86c7f2022-12-21T22:59:22ZengMDPI AGViruses1999-49152019-08-0111875110.3390/v11080751v11080751<i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA VirusesLaura R. Newburn0K. Andrew White1Department of Biology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Biology, York University, Toronto, ON M3J 1P3, CanadaRNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in different forms, including double-stranded RNA, coding-sense single-stranded RNA, and noncoding single-stranded RNA. Genera that possess these genome types include, respectively, <i>Orbivirus</i> (e.g., Bluetongue virus), <i>Dianthovirus</i> (e.g., Red clover necrotic mosaic virus) and <i>Alphainfluenzavirus</i> (e.g., Influenza A virus). Despite their distinct genomic features and diverse host ranges (i.e., animals, plants, and humans, respectively) each of these viruses uses <i>trans</i>-acting RNA−RNA interactions (tRRIs) to facilitate co-packaging of their segmented genome. The tRRIs occur between different viral genome segments and direct the selective packaging of a complete genome complement. Here we explore the current state of understanding of tRRI-mediated co-packaging in the abovementioned viruses and examine other known and potential functions for this class of RNA−RNA interaction.https://www.mdpi.com/1999-4915/11/8/751RNA structureRNA–RNA interactionsRNA virusRNA packagingsegmented virusinfluenza virusbluetongue virusreovirusred clover necrotic mosaic virus |
| spellingShingle | Laura R. Newburn K. Andrew White <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses Viruses RNA structure RNA–RNA interactions RNA virus RNA packaging segmented virus influenza virus bluetongue virus reovirus red clover necrotic mosaic virus |
| title | <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses |
| title_full | <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses |
| title_fullStr | <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses |
| title_full_unstemmed | <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses |
| title_short | <i>Trans</i>-Acting RNA–RNA Interactions in Segmented RNA Viruses |
| title_sort | i trans i acting rna rna interactions in segmented rna viruses |
| topic | RNA structure RNA–RNA interactions RNA virus RNA packaging segmented virus influenza virus bluetongue virus reovirus red clover necrotic mosaic virus |
| url | https://www.mdpi.com/1999-4915/11/8/751 |
| work_keys_str_mv | AT laurarnewburn itransiactingrnarnainteractionsinsegmentedrnaviruses AT kandrewwhite itransiactingrnarnainteractionsinsegmentedrnaviruses |