Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study
Abstract Objective Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study whi...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4751-9 |
| _version_ | 1818238035196641280 |
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| author | Osman Sianipar Widya Asmara Iwan Dwiprahasto Budi Mulyono |
| author_facet | Osman Sianipar Widya Asmara Iwan Dwiprahasto Budi Mulyono |
| author_sort | Osman Sianipar |
| collection | DOAJ |
| description | Abstract Objective Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which involved 72 patients was conducted to assess the risk of mortality of bloodstream infection due to ESBL-producing K. pneumoniae or E. coli as compared to those infected by either K. pneumoniae or E. coli which not produce ESBL. Result Mortality in the group of patients infected with ESBL-producing bacteria was 30.6%, whereas in another group which was infected with non ESBL-producing bacteria was 22.2% (p = 0.59). Kaplan–Meier’s analysis showed that the survival rate during 14-days follow-up among these two group was not significantly different (p = 0.45) with hazard ratio 1.41 (95% CI 0.568–3.51). Stratification analysis found that adult and elderly patients, patients with sign of leukocytosis, and patients treated with carbapenem were modifier effect variables. |
| first_indexed | 2024-12-12T12:35:15Z |
| format | Article |
| id | doaj.art-43487a11a5c84d1cb9801175f89c44d2 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-12T12:35:15Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-43487a11a5c84d1cb9801175f89c44d22022-12-22T00:24:21ZengBMCBMC Research Notes1756-05002019-11-011211710.1186/s13104-019-4751-9Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort studyOsman Sianipar0Widya Asmara1Iwan Dwiprahasto2Budi Mulyono3Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaDepartment of Microbiology, Faculty of Veterinary Medicine, Universitas Gadjah MadaDepartment of Pharmacology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaDepartment of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaAbstract Objective Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which involved 72 patients was conducted to assess the risk of mortality of bloodstream infection due to ESBL-producing K. pneumoniae or E. coli as compared to those infected by either K. pneumoniae or E. coli which not produce ESBL. Result Mortality in the group of patients infected with ESBL-producing bacteria was 30.6%, whereas in another group which was infected with non ESBL-producing bacteria was 22.2% (p = 0.59). Kaplan–Meier’s analysis showed that the survival rate during 14-days follow-up among these two group was not significantly different (p = 0.45) with hazard ratio 1.41 (95% CI 0.568–3.51). Stratification analysis found that adult and elderly patients, patients with sign of leukocytosis, and patients treated with carbapenem were modifier effect variables.http://link.springer.com/article/10.1186/s13104-019-4751-9Bloodstream infectionK. pneumoniaeE. coliExtended-spectrum β-lactamaseMortality |
| spellingShingle | Osman Sianipar Widya Asmara Iwan Dwiprahasto Budi Mulyono Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study BMC Research Notes Bloodstream infection K. pneumoniae E. coli Extended-spectrum β-lactamase Mortality |
| title | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
| title_full | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
| title_fullStr | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
| title_full_unstemmed | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
| title_short | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
| title_sort | mortality risk of bloodstream infection caused by either escherichia coli or klebsiella pneumoniae producing extended spectrum β lactamase a prospective cohort study |
| topic | Bloodstream infection K. pneumoniae E. coli Extended-spectrum β-lactamase Mortality |
| url | http://link.springer.com/article/10.1186/s13104-019-4751-9 |
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