The regulation of cellular metabolism by tumor suppressor p53
<p>Abstract</p> <p>As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function in tumo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-02-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | http://www.cellandbioscience.com/content/3/1/9 |
| _version_ | 1818513678233763840 |
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| author | Liang Yingjian Liu Juan Feng Zhaohui |
| author_facet | Liang Yingjian Liu Juan Feng Zhaohui |
| author_sort | Liang Yingjian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function in tumor suppression through its transcriptional regulation of its target genes to initiate various cellular responses. Cell cycle arrest, apoptosis and senescence are most well-understood functions of p53, and are traditionally accepted as the major mechanisms for p53 in tumor suppression. Recent studies have revealed a novel function of p53 in regulation of cellular metabolism. p53 regulates mitochondrial oxidative phosphorylation, glycolysis, glutamine metabolism, lipid metabolism, and antioxidant defense. Through the regulation of these metabolic processes, p53 maintains the homeostasis of cellular metabolism and redox balance in cells, which contributes significantly to the role of p53 as a tumor suppressor. Further understanding of the role and molecular mechanism of p53 in cellular metabolism could lead to the identification of novel targets and development of novel strategies for tumor therapy.</p> |
| first_indexed | 2024-12-11T00:04:56Z |
| format | Article |
| id | doaj.art-434965e485f648c7add075c7e1500b0c |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-11T00:04:56Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-434965e485f648c7add075c7e1500b0c2022-12-22T01:28:21ZengBMCCell & Bioscience2045-37012013-02-0131910.1186/2045-3701-3-9The regulation of cellular metabolism by tumor suppressor p53Liang YingjianLiu JuanFeng Zhaohui<p>Abstract</p> <p>As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function in tumor suppression through its transcriptional regulation of its target genes to initiate various cellular responses. Cell cycle arrest, apoptosis and senescence are most well-understood functions of p53, and are traditionally accepted as the major mechanisms for p53 in tumor suppression. Recent studies have revealed a novel function of p53 in regulation of cellular metabolism. p53 regulates mitochondrial oxidative phosphorylation, glycolysis, glutamine metabolism, lipid metabolism, and antioxidant defense. Through the regulation of these metabolic processes, p53 maintains the homeostasis of cellular metabolism and redox balance in cells, which contributes significantly to the role of p53 as a tumor suppressor. Further understanding of the role and molecular mechanism of p53 in cellular metabolism could lead to the identification of novel targets and development of novel strategies for tumor therapy.</p>http://www.cellandbioscience.com/content/3/1/9p53Tumor suppressorCancer metabolismThe Warburg effectGlycolysisOxidative phosphorylationLipid metabolismGlutaminolysisAntioxidant defense |
| spellingShingle | Liang Yingjian Liu Juan Feng Zhaohui The regulation of cellular metabolism by tumor suppressor p53 Cell & Bioscience p53 Tumor suppressor Cancer metabolism The Warburg effect Glycolysis Oxidative phosphorylation Lipid metabolism Glutaminolysis Antioxidant defense |
| title | The regulation of cellular metabolism by tumor suppressor p53 |
| title_full | The regulation of cellular metabolism by tumor suppressor p53 |
| title_fullStr | The regulation of cellular metabolism by tumor suppressor p53 |
| title_full_unstemmed | The regulation of cellular metabolism by tumor suppressor p53 |
| title_short | The regulation of cellular metabolism by tumor suppressor p53 |
| title_sort | regulation of cellular metabolism by tumor suppressor p53 |
| topic | p53 Tumor suppressor Cancer metabolism The Warburg effect Glycolysis Oxidative phosphorylation Lipid metabolism Glutaminolysis Antioxidant defense |
| url | http://www.cellandbioscience.com/content/3/1/9 |
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