Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants
The zebrafish (<i>Danio rerio</i>) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotox...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/9/10/1345 |
| _version_ | 1797551272842231808 |
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| author | Amir Modarresi Chahardehi Hasni Arsad Vuanghao Lim |
| author_facet | Amir Modarresi Chahardehi Hasni Arsad Vuanghao Lim |
| author_sort | Amir Modarresi Chahardehi |
| collection | DOAJ |
| description | The zebrafish (<i>Danio rerio</i>) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research. |
| first_indexed | 2024-03-10T15:42:13Z |
| format | Article |
| id | doaj.art-4349b72d64e04f4eb5ae459cfc8602d1 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T15:42:13Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-4349b72d64e04f4eb5ae459cfc8602d12023-11-20T16:44:59ZengMDPI AGPlants2223-77472020-10-01910134510.3390/plants9101345Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal PlantsAmir Modarresi Chahardehi0Hasni Arsad1Vuanghao Lim2Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, MalaysiaIntegrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, MalaysiaIntegrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, MalaysiaThe zebrafish (<i>Danio rerio</i>) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research.https://www.mdpi.com/2223-7747/9/10/1345zebrafishtoxicityembryotoxicitymedicinal plantanimal model |
| spellingShingle | Amir Modarresi Chahardehi Hasni Arsad Vuanghao Lim Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants Plants zebrafish toxicity embryotoxicity medicinal plant animal model |
| title | Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants |
| title_full | Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants |
| title_fullStr | Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants |
| title_full_unstemmed | Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants |
| title_short | Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants |
| title_sort | zebrafish as a successful animal model for screening toxicity of medicinal plants |
| topic | zebrafish toxicity embryotoxicity medicinal plant animal model |
| url | https://www.mdpi.com/2223-7747/9/10/1345 |
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