EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

Abstract Background Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient levels of intracellular amino acids, such as leucine, which are required...

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Bibliographic Details
Main Authors: Blake K. Zhang, Anne M. Moran, Charles G. Bailey, John E. J. Rasko, Jeff Holst, Qian Wang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell Communication and Signaling
Subjects:
EGF
PI3K/Akt signalling pathway
L-type amino acids transporter 3
LAT3
SLC43A1
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s12964-019-0400-0

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