Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis
Abstract Background In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the cli...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-019-0843-5 |
| _version_ | 1828886225336926208 |
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| author | Ji Soo Choi Sang Hoon Lee Ah. Young Leem Joo Han Song Kyung Soo Chung Ji Ye Jung Young Ae Kang Moo Suk Park Young Sam Kim Joon Chang Song Yee Kim |
| author_facet | Ji Soo Choi Sang Hoon Lee Ah. Young Leem Joo Han Song Kyung Soo Chung Ji Ye Jung Young Ae Kang Moo Suk Park Young Sam Kim Joon Chang Song Yee Kim |
| author_sort | Ji Soo Choi |
| collection | DOAJ |
| description | Abstract Background In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF). Methods We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. The primary outcomes were death and lung transplantation. The patients were followed up until June 2017. Results One hundred and eight patients (35.6%) died and 58 (19.1%) underwent lung transplantation during follow-up. The mean mPA and Ao diameters were 28.3 mm and 34.0 mm, respectively, and the mean mPA/Ao ratio was 0.84. Thirty-one patients (10.2%) had an mPA/Ao ratio > 1.0 and 182 (60.1%) had an mPA/Ao ratio > 0.8. Patients with an mPA/Ao ratio > 0.8 had a lower DLco value than those with an mPA/Ao ratio ≤ 0.8. In Kaplan-Meier analysis, patients with an mPA/Ao ratio > 1.0 or > 0.8 had worse outcomes than those with an mPA/Ao ratio ≤ 1.0 and ≤ 0.8, respectively. Conclusions A higher mPA/Ao ratio based on 1.0 and 0.8 is associated with unfavorable prognosis in patients with IPF. |
| first_indexed | 2024-12-13T11:40:55Z |
| format | Article |
| id | doaj.art-434e90c2f4f04dfaab4cdbaae5c3ce78 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-13T11:40:55Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-434e90c2f4f04dfaab4cdbaae5c3ce782022-12-21T23:47:38ZengBMCBMC Pulmonary Medicine1471-24662019-04-011911810.1186/s12890-019-0843-5Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosisJi Soo Choi0Sang Hoon Lee1Ah. Young Leem2Joo Han Song3Kyung Soo Chung4Ji Ye Jung5Young Ae Kang6Moo Suk Park7Young Sam Kim8Joon Chang9Song Yee Kim10Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineAbstract Background In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF). Methods We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. The primary outcomes were death and lung transplantation. The patients were followed up until June 2017. Results One hundred and eight patients (35.6%) died and 58 (19.1%) underwent lung transplantation during follow-up. The mean mPA and Ao diameters were 28.3 mm and 34.0 mm, respectively, and the mean mPA/Ao ratio was 0.84. Thirty-one patients (10.2%) had an mPA/Ao ratio > 1.0 and 182 (60.1%) had an mPA/Ao ratio > 0.8. Patients with an mPA/Ao ratio > 0.8 had a lower DLco value than those with an mPA/Ao ratio ≤ 0.8. In Kaplan-Meier analysis, patients with an mPA/Ao ratio > 1.0 or > 0.8 had worse outcomes than those with an mPA/Ao ratio ≤ 1.0 and ≤ 0.8, respectively. Conclusions A higher mPA/Ao ratio based on 1.0 and 0.8 is associated with unfavorable prognosis in patients with IPF.http://link.springer.com/article/10.1186/s12890-019-0843-5Pulmonary arteryIdiopathic pulmonary fibrosisPrognosis |
| spellingShingle | Ji Soo Choi Sang Hoon Lee Ah. Young Leem Joo Han Song Kyung Soo Chung Ji Ye Jung Young Ae Kang Moo Suk Park Young Sam Kim Joon Chang Song Yee Kim Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis BMC Pulmonary Medicine Pulmonary artery Idiopathic pulmonary fibrosis Prognosis |
| title | Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| title_full | Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| title_fullStr | Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| title_full_unstemmed | Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| title_short | Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| title_sort | prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis |
| topic | Pulmonary artery Idiopathic pulmonary fibrosis Prognosis |
| url | http://link.springer.com/article/10.1186/s12890-019-0843-5 |
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