Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein

Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein

Cellular prion protein (PrPC) protects neurons against oxidative stress damage. This role is lost upon its misfolding into insoluble prions in prion diseases, and correlated with cytoskeletal breakdown and neurophysiological deficits. Here we used mouse neuronal models to assess how PrPC protects th...

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Bibliographic Details
Main Authors: Simote T. Foliaki, Aleksandar Wood, Katie Williams, Anna Smith, Ryan O. Walters, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
Subjects:
Oxidative stress
PrP
Prion disease
Prion protein
Neuronal cytoskeleton
Hippocampal CA1 long-term potentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001349

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