APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors

APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors

Abstract The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the...

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Bibliographic Details
Main Authors: Chunyan Zong, Zhe Zhang, Li Gao, Jie He, Yiran Wang, Qian Li, Xiaoting Liu, Jie Yang, Di Chen, Rui Huang, Guopei Zheng, Xiaoliang Jin, Wu Wei, Renbing Jia, Jianfeng Shen
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05867-0

Internet

https://doi.org/10.1038/s41419-023-05867-0

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