Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
ABSTRACT Objective To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. Methods In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor Syst...
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| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2023-07-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100221&tlng=en |
| _version_ | 1797773136501932032 |
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| author | Thiago Domingos Corrêa Thais Dias Midega Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Roberto Rabello Filho Bruno Caldin da Silva Moacyr Silva Júnior Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Gustavo Faissol Janot de Matos Neide Marcela Lucinio Rodrigo Dias Rodrigues Raquel Afonso Caserta Eid Bruno de Arruda Bravim Adriano José Pereira Bento Fortunato Cardoso dos Santos João Renato Rebello Pinho Andreia Pardini Vanessa Damazio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz |
| author_facet | Thiago Domingos Corrêa Thais Dias Midega Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Roberto Rabello Filho Bruno Caldin da Silva Moacyr Silva Júnior Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Gustavo Faissol Janot de Matos Neide Marcela Lucinio Rodrigo Dias Rodrigues Raquel Afonso Caserta Eid Bruno de Arruda Bravim Adriano José Pereira Bento Fortunato Cardoso dos Santos João Renato Rebello Pinho Andreia Pardini Vanessa Damazio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz |
| author_sort | Thiago Domingos Corrêa |
| collection | DOAJ |
| description | ABSTRACT Objective To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. Methods In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in São Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. Results In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. Conclusion In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission. |
| first_indexed | 2024-03-12T22:00:55Z |
| format | Article |
| id | doaj.art-4350c4f8921c4dff8a93d7cf4b8418c2 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-03-12T22:00:55Z |
| publishDate | 2023-07-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-4350c4f8921c4dff8a93d7cf4b8418c22023-07-25T07:42:09ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852023-07-012110.31744/einstein_journal/2023ao0233Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort studyThiago Domingos Corrêahttps://orcid.org/0000-0001-9546-3910Thais Dias Midegahttps://orcid.org/0000-0002-1010-3711Ricardo Luiz Cordiolihttps://orcid.org/0000-0001-7521-399XCarmen Silvia Valente Barbashttps://orcid.org/0000-0002-3922-6256Roberto Rabello Filhohttps://orcid.org/0000-0001-7018-224XBruno Caldin da Silvahttps://orcid.org/0000-0001-9568-0974Moacyr Silva Júniorhttps://orcid.org/0000-0002-6479-1708Ricardo Kenji Nawahttps://orcid.org/0000-0002-0852-7013Fabrício Rodrigues Torres de Carvalhohttps://orcid.org/0000-0001-8712-269XGustavo Faissol Janot de Matoshttps://orcid.org/0000-0001-9996-7040Neide Marcela Luciniohttps://orcid.org/0009-0002-2173-222XRodrigo Dias Rodrigueshttps://orcid.org/0009-0008-1648-9986Raquel Afonso Caserta Eidhttps://orcid.org/0000-0002-8241-3241Bruno de Arruda Bravimhttps://orcid.org/0000-0001-8290-8554Adriano José Pereirahttps://orcid.org/0000-0002-9467-6516Bento Fortunato Cardoso dos Santoshttps://orcid.org/0000-0002-4662-1959João Renato Rebello Pinhohttps://orcid.org/0000-0003-3999-0489Andreia Pardinihttps://orcid.org/0000-0002-9810-0100Vanessa Damazio Teichhttps://orcid.org/0000-0002-8539-6037Claudia Regina Laselvahttps://orcid.org/0000-0001-8285-9633Miguel Cendoroglo Netohttps://orcid.org/0000-0002-8163-4392Sidney Klajnerhttps://orcid.org/0000-0003-4120-1047Leonardo José Rolim Ferrazhttps://orcid.org/0000-0003-1822-1568ABSTRACT Objective To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. Methods In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in São Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. Results In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. Conclusion In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100221&tlng=enCoronavirus infectionsCOVID-19SARS-CoV-2Respiration, artificialNoninvasive ventilationExtracorporeal membrane oxygenationCritical care outcomesMortalityIntensive care units |
| spellingShingle | Thiago Domingos Corrêa Thais Dias Midega Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Roberto Rabello Filho Bruno Caldin da Silva Moacyr Silva Júnior Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Gustavo Faissol Janot de Matos Neide Marcela Lucinio Rodrigo Dias Rodrigues Raquel Afonso Caserta Eid Bruno de Arruda Bravim Adriano José Pereira Bento Fortunato Cardoso dos Santos João Renato Rebello Pinho Andreia Pardini Vanessa Damazio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study Einstein (São Paulo) Coronavirus infections COVID-19 SARS-CoV-2 Respiration, artificial Noninvasive ventilation Extracorporeal membrane oxygenation Critical care outcomes Mortality Intensive care units |
| title | Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study |
| title_full | Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study |
| title_fullStr | Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study |
| title_full_unstemmed | Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study |
| title_short | Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study |
| title_sort | clinical characteristics and outcomes of patients with covid 19 admitted to the intensive care unit during the first and second waves of the pandemic in brazil a single center retrospective cohort study |
| topic | Coronavirus infections COVID-19 SARS-CoV-2 Respiration, artificial Noninvasive ventilation Extracorporeal membrane oxygenation Critical care outcomes Mortality Intensive care units |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100221&tlng=en |
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