Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?

There are a number of genetic syndromes associated with both high cancer risk and clinical radiosensitivity. However, the link between these two notions remains unknown. Particularly, some cancer syndromes are caused by mutations in genes involved in DNA damage signaling and repair. How are the DNA...

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Bibliographic Details
Main Authors: Laura El Nachef, Elise Berthel, Mélanie L. Ferlazzo, Eymeric Le Reun, Joelle Al-Choboq, Juliette Restier-Verlet, Adeline Granzotto, Laurène Sonzogni, Michel Bourguignon, Nicolas Foray
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
cancer
genetic syndromes
radiosensitivity
ATM protein
Online Access:https://www.mdpi.com/2072-6694/14/24/6141

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