Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

The formation of hypoxic microenvironments within solid tumors is known to contribute to radiation resistance, chemotherapy resistance, immune suppression, increased metastasis, and an overall poor prognosis. It is therefore crucial to understand the spatial and molecular mechanisms that contribute...

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Bibliographic Details
Main Authors: Mark Zaidi, Fred Fu, Dan Cojocari, Trevor D. McKee, Bradly G. Wouters
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hypoxia
tumor microenvironment
digital pathology
immunofluorescence
image analysis
distance mapping
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00397/full

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