Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test
Platelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subj...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2020-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/full_html/2020/12/bioconf_biomic2020_03003/bioconf_biomic2020_03003.html |
| _version_ | 1818453153893318656 |
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| author | Anindita Sumitro Nandini Winda Kusumadewi Wiwin Yuniawati Fitri Amalia Naila Hendrawati Hendrawati Murdiastuti Kwartarini |
| author_facet | Anindita Sumitro Nandini Winda Kusumadewi Wiwin Yuniawati Fitri Amalia Naila Hendrawati Hendrawati Murdiastuti Kwartarini |
| author_sort | Anindita Sumitro Nandini |
| collection | DOAJ |
| description | Platelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subjected to crossmatch testing in clinics to prevent any immune response in recipients. The present study aimed to evaluate the differences in donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP (FD h-PRP). This was a laboratory experiment, h-PRP prepared according to the protocol of blood bank, and 40 recipients blood samples divided into two groups, fresh h-PRP (control group) and FD h-PRP. The crossmatch test was performed to evaluate h-PRP compatibilities by using the gel-test method. The data were analyzed using the chi-square test. The results of the study showed that the crossmatch test on FD h-PRP samples was 100 % compatible and could increase the compatibility results of the donor. the FD h-PRP was safe to become donors and clinical applications. |
| first_indexed | 2024-12-14T21:34:28Z |
| format | Article |
| id | doaj.art-435290d673d643cca0e811cb0b4424a0 |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-12-14T21:34:28Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-435290d673d643cca0e811cb0b4424a02022-12-21T22:46:36ZengEDP SciencesBIO Web of Conferences2117-44582020-01-01280300310.1051/bioconf/20202803003bioconf_biomic2020_03003Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch testAnindita Sumitro Nandini0Winda Kusumadewi Wiwin1Yuniawati Fitri2Amalia Naila3Hendrawati Hendrawati4Murdiastuti Kwartarini5Clinical Dentistry Program, Faculty of Dentistry, Universitas Gadjah MadaClinical Dentistry Program, Faculty of Dentistry, Universitas Gadjah MadaClinical Dentistry Program, Faculty of Dentistry, Universitas Gadjah MadaBlood Transfusion Unit, Palang Merah IndonesiaDepartment of Periodontology, Faculty of Dentistry, Universitas Gadjah MadaDepartment of Periodontology, Faculty of Dentistry, Universitas Gadjah MadaPlatelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subjected to crossmatch testing in clinics to prevent any immune response in recipients. The present study aimed to evaluate the differences in donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP (FD h-PRP). This was a laboratory experiment, h-PRP prepared according to the protocol of blood bank, and 40 recipients blood samples divided into two groups, fresh h-PRP (control group) and FD h-PRP. The crossmatch test was performed to evaluate h-PRP compatibilities by using the gel-test method. The data were analyzed using the chi-square test. The results of the study showed that the crossmatch test on FD h-PRP samples was 100 % compatible and could increase the compatibility results of the donor. the FD h-PRP was safe to become donors and clinical applications.https://www.bio-conferences.org/articles/bioconf/full_html/2020/12/bioconf_biomic2020_03003/bioconf_biomic2020_03003.html |
| spellingShingle | Anindita Sumitro Nandini Winda Kusumadewi Wiwin Yuniawati Fitri Amalia Naila Hendrawati Hendrawati Murdiastuti Kwartarini Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test BIO Web of Conferences |
| title | Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test |
| title_full | Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test |
| title_fullStr | Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test |
| title_full_unstemmed | Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test |
| title_short | Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test |
| title_sort | differences in donor compatibility for fresh and freeze dried homologous platelet rich plasma studied using crossmatch test |
| url | https://www.bio-conferences.org/articles/bioconf/full_html/2020/12/bioconf_biomic2020_03003/bioconf_biomic2020_03003.html |
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