Protective Antigen-Specific Memory B Cells Persist Years after Anthrax Vaccination and Correlate with Humoral Immunity

Protective Antigen-Specific Memory B Cells Persist Years after Anthrax Vaccination and Correlate with Humoral Immunity

Anthrax Vaccine Adsorbed (AVA) generates short-lived protective antigen (PA) specific IgG that correlates with in vitro toxin neutralization and protection from Bacillus anthracis challenge. Animal studies suggest that when PA-specific IgG has waned, survival after spore challenge correlates with a...

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Bibliographic Details
Main Authors: Lori Garman, Kenneth Smith, A. Darise Farris, Michael R. Nelson, Renata J. M. Engler, Judith A. James
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Toxins
Subjects:
Anthrax Vaccine Adsorbed
cellular immunity
lethal toxin neutralization
protective antigen
Online Access:http://www.mdpi.com/2072-6651/6/8/2424

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