Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals
Abstract Aims This study aimed to evaluate the prognostic effect of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) for patients with breast cancer (BC). Methods A literature search was performed by searching medical databases. Basic characteristics and prognostic data we...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2281 |
| _version_ | 1818516761508577280 |
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| author | Wanying Guo Xin Lu Qipeng Liu Ting Zhang Peng Li Weiqiang Qiao Miao Deng |
| author_facet | Wanying Guo Xin Lu Qipeng Liu Ting Zhang Peng Li Weiqiang Qiao Miao Deng |
| author_sort | Wanying Guo |
| collection | DOAJ |
| description | Abstract Aims This study aimed to evaluate the prognostic effect of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) for patients with breast cancer (BC). Methods A literature search was performed by searching medical databases. Basic characteristics and prognostic data were extracted from included studies. Primary outcomes, such as overall survival (OS) and disease‐free survival (DFS), were synthesized and compared. Subgroup analyses were performed according to pathology, geographical region, cut‐off value, and tumor progression. Results A total of 39 studies comprising 17079 BC patients were included in this meta‐analysis. Among them, 28 studies with 142 64 BC patients investigated predicting role of NLR for OS, showing elevated NLR were associated poor prognosis (hazard ratio [HR]: 1.78, 95% confidence interval [CI]: 1.49‐2.13, P < 0.001). Twenty‐seven studies containing 115 04 patients explored the role of NLR in predicting DFS, showing elevated NLR was associated with poor DFS with HR of 1.60 (95% CI: 1.42‐1.96, P < 0.001). Twelve studies explored the role of PLR in predicting OS, showing patients with higher PLR were associated with a significantly worse prognosis with a pooled HR of 1.32 (95% CI: 1.11‐1.57, P = 0.002). Eleven studies with 5013 patients shown patients with elevated PLR were associated shorter DFS (HR: 1.43, 95% CI: 1.09‐1.86, P = 0.009). Subgroup analyses shown a greater magnitude of association between NLR and OS in triple‐negative BC patients than in HER2‐positive ones. Conclusions Our study suggested that elevated NLR and PLR were associated with poor OS as well as high risk of recurrence for BC patients. Subgroup analyses confirmed the prognostic effect of NLR and PLR in HER2‐positive BC patients. As easily accessible parameters, NLR and PLR should be identified as useful biomarkers in the management of BC. |
| first_indexed | 2024-12-11T00:46:31Z |
| format | Article |
| id | doaj.art-4353f549647e454ebc39f01337eb3276 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-11T00:46:31Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-4353f549647e454ebc39f01337eb32762022-12-22T01:26:46ZengWileyCancer Medicine2045-76342019-08-01894135414810.1002/cam4.2281Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individualsWanying Guo0Xin Lu1Qipeng Liu2Ting Zhang3Peng Li4Weiqiang Qiao5Miao Deng6Department of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Gastrointestinal Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaDepartment of Breast Surgery The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang ChinaAbstract Aims This study aimed to evaluate the prognostic effect of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) for patients with breast cancer (BC). Methods A literature search was performed by searching medical databases. Basic characteristics and prognostic data were extracted from included studies. Primary outcomes, such as overall survival (OS) and disease‐free survival (DFS), were synthesized and compared. Subgroup analyses were performed according to pathology, geographical region, cut‐off value, and tumor progression. Results A total of 39 studies comprising 17079 BC patients were included in this meta‐analysis. Among them, 28 studies with 142 64 BC patients investigated predicting role of NLR for OS, showing elevated NLR were associated poor prognosis (hazard ratio [HR]: 1.78, 95% confidence interval [CI]: 1.49‐2.13, P < 0.001). Twenty‐seven studies containing 115 04 patients explored the role of NLR in predicting DFS, showing elevated NLR was associated with poor DFS with HR of 1.60 (95% CI: 1.42‐1.96, P < 0.001). Twelve studies explored the role of PLR in predicting OS, showing patients with higher PLR were associated with a significantly worse prognosis with a pooled HR of 1.32 (95% CI: 1.11‐1.57, P = 0.002). Eleven studies with 5013 patients shown patients with elevated PLR were associated shorter DFS (HR: 1.43, 95% CI: 1.09‐1.86, P = 0.009). Subgroup analyses shown a greater magnitude of association between NLR and OS in triple‐negative BC patients than in HER2‐positive ones. Conclusions Our study suggested that elevated NLR and PLR were associated with poor OS as well as high risk of recurrence for BC patients. Subgroup analyses confirmed the prognostic effect of NLR and PLR in HER2‐positive BC patients. As easily accessible parameters, NLR and PLR should be identified as useful biomarkers in the management of BC.https://doi.org/10.1002/cam4.2281breast cancermeta‐analysisneutrophil‐to‐lymphocyte ratioplatelet‐to‐lymphocyte ratioprognosis |
| spellingShingle | Wanying Guo Xin Lu Qipeng Liu Ting Zhang Peng Li Weiqiang Qiao Miao Deng Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals Cancer Medicine breast cancer meta‐analysis neutrophil‐to‐lymphocyte ratio platelet‐to‐lymphocyte ratio prognosis |
| title | Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals |
| title_full | Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals |
| title_fullStr | Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals |
| title_full_unstemmed | Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals |
| title_short | Prognostic value of neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio for breast cancer patients: An updated meta‐analysis of 17079 individuals |
| title_sort | prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for breast cancer patients an updated meta analysis of 17079 individuals |
| topic | breast cancer meta‐analysis neutrophil‐to‐lymphocyte ratio platelet‐to‐lymphocyte ratio prognosis |
| url | https://doi.org/10.1002/cam4.2281 |
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